Product Description for 6CKine / CCL21
6CKine / CCL21.
Properties for 6CKine / CCL21
| Product Category | Proteins |
|---|---|
| Quantity | 5 µg |
| Synonyms | Beta chemokine Exodus-2, CCL-21, SCYA21, SLC, Secondary lymphoid-tissue chemokine, Small-inducible cytokine A21 |
| Molecular weight | 12.2 kD |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | >98% |
| Add. information | Centrifuge the vial prior to opening! |
| Background | Exodus-2 is a CC chemokine that signals through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant human Exodus-2 is a 12.2 kDa protein containing 111 amino acid residues. |
| References | 1. Yang D, Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses J Exp Med., 2008, 205(1):79-90. 2. Wilflingseder, D. IgG Opsonization of HIV Impedes Provirus Formation in and Infection of Dendritic Cells and Subsequent Long-Term Transfer to T Cells. The Journal of Immunology, 2007, 178(12):7840-8. 3. Huang, M.C. Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. The Journal of Immunology, 2007, 178(11):6806-13. 4. Friedman RS, Surface-bound chemokines capture and prime T cells for synapse formation Nat Immunol., 2006, 7(10):1101-8. 5. Angel CE Cutting Edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands J Immunol., 2006, 176(10):5730-4. |
| Storage | Prior to reconstitution the antibody can be stored at 2-8°C for one month or at -20°C for longer. Following reconstitution the antibody can be stored at -20°C to -80°C up to 3 month. It is recommended to further dilute in a buffer containing a carrier protein (exanple 0,1% BSA). Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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