AR03029PU-N Hsp90 inhibitor (Radicicol) antigen
see all 8 Hsp90 inhibitor products
1 mg / US$ 335
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Hsp90 inhibitor (Radicicol)
Product Description
Hsp90 inhibitor (Radicicol)
Properties
| Presentation | Purified |
| Purity | >97% |
| Molecular Weight | 364.8 |
| Catalog Number | AR03029PU-N |
| Quantity | 1 mg |
| Price | US$ 335 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  AR03029PU-N.pdf |
Datasheet Extract
| Background | Radicicol inhibits src (IC50=0.27μM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1. |
| Format | State: White to light yellow powder, produced by fermentation Purity: 97% by TLC Reconstitution: Soluble in DMSO |
| Description | Formula: C18H17CIO6 Molecular weight: 364.8 |
| Storage | Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing. Protect from light! Shelf life: One year from despatch. |
| References | 1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.
2. Yen A., et al. (1994) Exp.Cell Res. 214: 163. 3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221. 4. Soga S., et al. (1998) J.Biol.Chem. 273:822. 5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221. 6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260. |
| Pictures | Figure 1: Structure of Radicicol |
