DA3521 CD292 / BMPR1A / ALK3 antigen
see all 11 CD292 / BMPR1A / ALK3 products
0.1 mg / US$ 455
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human CD292 / BMPR1A / ALK3
Synonyms
BMPR1A, ACVRLK3, ALK3, EC 2.7.11.30,
SKR5, Activin receptor-like kinase 3, ALK-3, CD292, , Serine/threonine-protein kinase receptor R5, Bone morphogenetic protein receptor type-1A
Product Description
Human CD292 / BMPR1A / ALK3
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >90% |
| Source | Insect cells |
| Molecular Weight | 23 kD |
| Catalog Number | DA3521 |
| Swiss Prot. No. | P36894 |
| Quantity | 0.1 mg |
| Price | US$ 455 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  DA3521.pdf |
Datasheet Extract
| Background | The extracellular domain of human BMPR -IA was fused with a carboxy -terminal 6X histidine-tag. The monomeric glycoprotein was expressed in baculovirus infected insect cells. Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor 1A (BMPR -1A), also known as activin receptor-like kinase (ALK)-3, is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-b family cytokines. In contrast to the TGF-b receptor system in which the type I receptor does not bind TGF-b in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR -IB/ALK -6, and ActR-I/ALK -2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IA binds BMP-2 and -4 with high-affinity in solution and is a potent BMP-2/4 antagonist in vitro. BMPR-IA is ubiquitously expressed during embryogenesis. In adult tissues, BMPR-IA mRNA is also widely distributed; with the highest expression levels found in skeletal muscle. The extracellular domain of BMPR-IA shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IA are highly conserved and share 98% sequence identity.
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| Immunogen | Swiss Num.: P36894 |
| Source | Insect cells |
| Format | State: Lyophilized Purity: > 90 % by SDS-PAGE and silver staining BufferSystem: PBS without stabilizer Endotoxinlevel: < 0.1 ng per µg of BMPR-IA Reconstitution: It is recommended that PBS containing at least 0.1% HSA or BSA be added to the vial to prepare stock solution of not less than 100 µg/ml of BMPR-IA. |
| Description | Monomeric glycoprotein
Biological Activity: Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 1-3 µg/ml in the presence of 500 ng/ml of recombinant human BMP-2. |
| Storage | Lyophilized samples are stable for six months at -20°C to -70°C.
Upon reconstitution, this cytokine can be stored under sterile conditions at 2-4°C for one month or at -20°C to -70°C for three months. Avoid repeated freezing and thawing. |