GTX10496 Osteoprotegerin antibody
see related secondary antibodiessee all 22 Osteoprotegerin products
50 µg / no delivery possible
Quick Overview
Goat anti Osteoprotegerin
Synonyms
TNFRSF11B, OCIF, OPG, Osteoclastogenesis inhibitory factor,
Product Description
Goat anti Osteoprotegerin , Presentation: Aff - Purified. Product is tested for Enzyme Immunoassay ( E ), Neutralisation ( NEUT ), Western blot / Immunoblot ( WB )
Properties
| Applications | Enzyme Immunoassay ( E ), Neutralisation ( NEUT ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Goat |
| Isotype | IgG |
| Catalog Number | GTX10496 |
| Swiss Prot. No. | O00300 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Europe only |
| Manufacturer | GeneTex Inc. |
| Datasheet |  http://www.genetex.com/co ... |
Datasheet Extract
| Osteoprotegerin antibody | |
| Concentration | 0.1 mg/ml |
| Background | Osteoprotegrin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF), is a soluble secreted member of the TNFR superfamily that lacks cell attachment motifs. Like many other TNFRs, the aminoterminal portion contains four cysteine-rich repeats and the carboxy-terminal portion contains two death domain (DD) homologous motifs. Natural OPG exists predominantly as a disulfide-linked dimer. The only two ligands currently known for OPG are RANKL (OPGL, ODF, TRANCE) and TRAIL (APO2-L, TNF-related apoptosis-inducing ligand/apoptosis-2 ligand). TRAIL, which is also a membrane bound signaling receptor, is broadly expressed in a variety of tissues, but not in liver. TRAIL induces apoptosis independent of Fas. TRAIL can apparently neutralize the action of RANKL (OPGL) on OPG by competitive displacement. The roles of OPG and RANKL in osteoclastogenesis, apoptosis and the functioning immune system are under active investigation. Apparently the balance between OPG and RANKL is a key determinant in whether new bone tissue is formed or existing bone tissue is lost. In recent studies, daily injections of OPG into normal rats remarkably increased bone mineral density and bone volume and decreased the number of osteoclasts. Glucocorticoids, which can cause bone loss, inhibit gene expression for OPG and stimulate production of RANKL, whereas estrogen, which helps prevent osteoporesis in menopausal women, stimulates expression of the OPG gene. Injections of OPG also prevented bone and cartilage destruction in mice treated to develop arthritis, while not preventing inflammation. OPG or a variant of OPG engineered to be a more efficacious drug has the potential to stop bone loss in osteoporosis and T cell disorders. OPG and RANKL are undergoing clinical trials for use in osteoporosis and related disorders. |
| Immunogen | Purified recombinant human osteoprotegerin (rhOPG), expressed in the insect cell line Sf 21. Swiss Num.: O00300 |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: Preservative: NoneConstituents: PBS |
| Applications | ELISA, Neut, WB |
| Specificity | Cross-reacts with Human. Mouse (50% cross-reactivity). Not yet tested in other species. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1317B | Goat IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1317F | Goat IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 305 | |||||
| R1317T | Goat IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 305 | |||||
| R1317TR | Goat IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 305 | |||||
| R1317HRP | Goat IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1317AP | Goat IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1435C2 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy2 | 1 mg / US$ 455 | |||||
| R1435C3 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy3 | 1 mg / US$ 455 | |||||
| R1435C35 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy3.5 | 1 mg / US$ 455 | |||||
| R1435C5 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy5 | 1 mg / US$ 485 | |||||
| R1435C55 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy5.5 | 1 mg / US$ 455 | |||||
| R1416R | Goat IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 465 | |||||
Click here to see all secondary antibodies for 'GTX10496 Osteoprotegerin'.
