GTX10962 Osteoprotegerin antibody
see related secondary antibodiessee all 22 Osteoprotegerin products
25 µg / no delivery possible
Quick Overview
Goat anti Osteoprotegerin
Synonyms
TNFRSF11B, OCIF, OPG, Osteoclastogenesis inhibitory factor,
Product Description
Goat anti Osteoprotegerin , Presentation: Aff - Purified. Product is tested for Enzyme Immunoassay ( E ), Neutralisation ( NEUT ), Western blot / Immunoblot ( WB )
Properties
| Applications | Enzyme Immunoassay ( E ), Neutralisation ( NEUT ), Western blot / Immunoblot ( WB ) |
| Reactivity | Mouse ( Ms ), Human ( Hu ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Goat |
| Isotype | IgG |
| Catalog Number | GTX10962 |
| Swiss Prot. No. | O00300 |
| Quantity | 25 µg |
| Price | no delivery possible |
| Delivery | Europe only |
| Manufacturer | GeneTex Inc. |
| Datasheet |  http://www.genetex.com/co ... |
Datasheet Extract
| Osteoprotegerin antibody | |
| Concentration | 0.1 mg/ml |
| Background | Osteoprotegerin, a member of the tumor necrosis factor receptor (TNFR) superfamily, is a soluble secreted protein that possesses no apparent cell-associated motifs. It is also referred to as osteoclastogenesis inhibitory factor (OCIF) and TNFRSF11B (TNF receptor superfamily, member 11B). Like many other TNFRs, the amino-terminal portion contains four cysteine-rich repeats and the carboxy-terminal portion contains two death domain (DD) homologous motifs. OPG was originally isolated by sequence homology as a TNF receptor family protein in fetal rat intestine and OCIF (initially believed to be a unique cytokine) was isolated from human embryonic fibroblasts. The only two ligands currently known for OPG are RANKL (OPGL, ODF, TRANCE) and TRAIL (APO2L, TNF related apoptosis-inducing ligand/apoptosis 2 ligand). TRAIL, which is also a membrane bound signaling receptor, is broadly expressed in a variety of tissues, but not in liver. TRAIL induces apoptosis independent of Fas. TRAIL can apparently neutralize the action of RANKL (OPGL) on OPG by competitive displacement. The roles of OPG and RANKL in osteoclastogenesis, apoptosis, and the functioning immune system are under active investigation. Apparently the balance between OPG and RANKL is a key determinant in whether new bone tissue is formed or existing bone tissue is lost. In recent studies, daily injections of OPG into normal rats remarkably increased bone mineral density and bone volume and decreased the number of osteoclasts. Glucocorticoids, which can cause bone loss, inhibit gene expression for OPG and stimulate production of RANKL, whereas estrogen, which helps prevent osteoporosis in menopausal women, stimulates expression of the OPG gene. Injections of OPG also prevented bone and cartilage destruction in mice treated to develop arthritis, while not preventing inflammation. OPG or a variant of OPG engineered to be a more efficacious drug has the potential to stop bone loss in osteoporosis and T cell disorders. Mouse OPG transcripts are expressed in liver, lung, heart, and kidney tissue. OPG mRNA is expressed at high levels in stomach, intestines, skin, and calvaria. In humans, high levels are detected in the lung, heart, kidney, and placenta. |
| Immunogen | Recombinant full length protein (Mouse) expressed in mouse NSO cells. Swiss Num.: O00300 |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: Preservative: 15mM sodium azide.Constituents: 0.01M PBS, 1% BSA. pH 7.4 |
| Applications | ELISA, Neut, WB |
| Specificity | Cross-reacts with Mouse. Expected to cross-react with Human (89% identity with immunogen) and Rat (93% identity with immunogen) due to sequence homology. Not yet tested in other species. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1317B | Goat IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1317F | Goat IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 305 | |||||
| R1317T | Goat IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 305 | |||||
| R1317TR | Goat IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 305 | |||||
| R1317HRP | Goat IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1317AP | Goat IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1435C2 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy2 | 1 mg / US$ 455 | |||||
| R1435C3 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy3 | 1 mg / US$ 455 | |||||
| R1435C35 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy3.5 | 1 mg / US$ 455 | |||||
| R1435C5 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy5 | 1 mg / US$ 485 | |||||
| R1435C55 | Goat IgG (H&L) multi-species ads. | ||||||
| Donkey | Cy5.5 | 1 mg / US$ 455 | |||||
| R1416R | Goat IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 465 | |||||
Click here to see all secondary antibodies for 'GTX10962 Osteoprotegerin'.
