GTX10982 Orexin-B antibody
see related secondary antibodiessee all 7 Orexin-B products
50 µl / no delivery possible
Quick Overview
Rabbit anti Orexin-B
Synonyms
HCRT, OX, PPORX, PPOX, Hypocretin-2, Hypocretin 2, Orexin B, Hypocretin,
Product Description
Rabbit anti Orexin-B , Presentation: Serum. Product is tested for Enzyme Immunoassay ( E ), Radioimmunoassay ( R )
Properties
| Applications | Enzyme Immunoassay ( E ), Radioimmunoassay ( R ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Serum |
| Host | Rabbit |
| Isotype | IgG |
| Catalog Number | GTX10982 |
| Swiss Prot. No. | P56717 |
| Quantity | 50 µl |
| Price | no delivery possible |
| Delivery | Europe only |
| Manufacturer | GeneTex Inc. |
| Datasheet |  http://www.genetex.com/co ... |
Datasheet Extract
| Orexin B antibody | |
| Concentration | 6 mg/ml |
| Background | The hypothalamus acts as a major regulatory center involved in the control of feeding behavior and energy homeostasis. Several neuropeptides and proteins have been shown to be involved in the regulation of these processes. Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B(hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro-orexin, which is encoded by a gene localized to human chromosome 17q21. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behavior. Prepro-orexin mRNA expression is upregulated upon fasting. Immunocytochemical mapping of Orexin A has identified a population of medium sized neurons within the hypothalamus, median eminence and ventral thalamic nuclei of the rat brain. This distribution has been confirmed in the human brain. Orexin-containing neurons diffusely innervate the entire brain, including monosynaptic projections to various regions of the cerebral cortex, limbic system, and brain stem. Orexin A and orexin B bind to and activate two closely related G protein-coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. OX1 receptor is selective for orexin A, whereas OX2 receptor is a nonselective receptor for both orexin A and orexin B. OX1 and OX2 mRNA are found in additional brain areas outside the hypothalamus, suggesting that orexin A and B may play additional regulatory roles in the central nervous system, such as arousal, locomotor activity and neuroendocrine functions. Dysfunction of the orexin peptide system has been linked to narcolepsy. Orexin knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as to canarc 1 mutant dogs, which carry a deletion in the OX2 receptor/Hcrtr2. |
| Immunogen | Synthetic peptide corresponding to the N-terminus of human Orexin B (amino acids 1-18 with C-terminally added lysine), conjugated to BSA as immunogen. This sequence is highly conserved (single amino acid substitution) in mouse and rat Orexin B and is diff Swiss Num.: P56717 |
| Format | Purification: Whole antiserum Purity: Whole antiserum BufferSystem: Preservative: 15mM sodium azide.Constituents: 0.01M PBS, 1% BSA. pH 7.4 |
| Applications | ELISA, RIA |
| Specificity | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Storage | Keep as concentrated solution. Store at 4 |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 305 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 295 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 295 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 305 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 305 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 335 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 455 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 455 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 455 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 455 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 455 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 465 | |||||
Click here to see all secondary antibodies for 'GTX10982 Orexin-B'.
