GTX27550 NFkB p50 peptide antigen
see all 2 NFkB p50 peptide products
50 µg / no delivery possible
Quick Overview
NFkB p50 peptide
Product Description
NFkB p50 peptide
Properties
| Catalog Number | GTX27550 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Europe only |
| Manufacturer | GeneTex Inc. |
| Datasheet |  http://www.genetex.com/co ... |
Datasheet Extract
| NFkB p50 peptide | |
| Concentration | 1 mg/ml |
| Background | NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. NF-kB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino-terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy-terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL-1alpha and TNF-alpha as mediated by IkB kinase and p38 MAPK. Serine 529 is located in a negatively charged region (amino acids 422-540) that is phosphorylated in response to phorbol myristate acetate plus calcium ionophore activation. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NF-kB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NF-kB has been associated with a number of inflammatory diseases while persistent inhibition of NF-kB leads to inappropriate immune cell development or delayed cell growth. |
| Immunogen | Not applicable |
| Format | State: Liquid (sterile filtered) Purification: n/a Purity: n/a BufferSystem: Antiserum containing 0.01% sodium azide |
| Applications | BL |
| Specificity | No Animal |
| Storage | Keep as concentrated solution. Aliquot and store at -20 |
