GTX28442 DFF45 / ICAD / DFFA Control Peptide antigen
see all 40 DFF45 / ICAD / DFFA products
50 µg / no delivery possible
Quick Overview
DFF45 / ICAD / DFFA
Synonyms
Inhibitor of CAD, DFF-45, DFF1, , DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit
Product review
Please read our product review about DFF45 / ICAD / DFFA: Antibodies to DNA Fragmentation Factor: DFF40 (CAD) and DFF45 (ICAD).
Product Description
DFF45 / ICAD / DFFA
Properties
| Catalog Number | GTX28442 |
| Swiss Prot. No. | O00273 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Europe only |
| Manufacturer | GeneTex Inc. |
| Datasheet |  http://www.genetex.com/co ... |
Datasheet Extract
| ICAD peptide | |
| Concentration | 0.2 mg/ml |
| Background | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the Caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by Caspase 3 during apoptosis. A mouse homologue of human DFF was identified as inhibitor of caspase activated deoxyribonuclease (ICAD). Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death. |
| Immunogen | Swiss Num.: O00273 |
| Format | Purification: n/a Purity: n/a BufferSystem: PBS with 0.1% BSA 0.02% sodium azide pH7.2 |
| Applications | BL, IHC, WB |
| Storage | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20 |