NB100-182H Fanconi anemia group D2 protein antibody
see related secondary antibodiessee all 16 Fanconi anemia group D2 protein products
0.05 ml / US$ 465 no delivery possible
Quick Overview
Rabbit anti Fanconi anemia group D2 protein
Synonyms
FANCD2, FACD,
Product Description
Rabbit anti Fanconi anemia group D2 protein , Presentation: HRP. Product is tested for Frozen sections ( C ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Frozen sections ( C ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ) |
| Presentation | HRP |
| Host | Rabbit |
| Catalog Number | NB100-182H |
| Swiss Prot. No. | Q9BXW9 |
| Quantity | 0.05 ml |
| Price | US$ 465 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Polyclonal anti-Fanconi anemia D2 , conjugated to HRP | |
| Alternate names | anti-FA4 antibody; anti-FACD antibody; anti-FAD antibody; anti-FAD2 antibody; anti-FANCD antibody; anti-Fanconi Anemia Complementation Group D antibody; anti-Fanconi Pancytopenia Type 4 antibody |
| Concentration | 1 mg/ml |
| Background | Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein. |
| Immunogen | Human FANCD2 fusion protein (N-terminal fragment). Swiss Num.: Q9BXW9 |
| Format | Purification: Affinity purified Purity: Affinity purified BufferSystem: PBS with 1% BSA |
| Applications | immunohistochemistry 2.5-5.0 ug/ml,,immunofluorescence 1:200-1:500,,immunoprecipitation ,,Western Blot 1:10000-1:20000 |
| Specificity | Species: NB 100-182 reacts with human and mouse FANCD2. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Bekker-Jensen, S., et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173: 195-206 (2006) 2. Dunn, J., P., et al. Activation of the Fanconi Anemia/BRCA Pathway and Recombination Repair in the Cellular Response to Solar Ultraviolet Light. Cancer Res. 66: 11140-11147 (2006) 3. Mukhopadhyay, S. S., et al. Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. JBC 175(2): 225-235 (2006) 4. Oda, T., et al. Hsp90 regulates the Fanconi anemia DNA damage response pathway. Blood-2006-2008-038638 (2007) 5. Tremblay, S., et al. Young Patients With Oral Squamous Cell Carcinoma: Study of the Involvement of GSTP1 and Deregulation of the Fanconi Anemia Genes. Arch Otolaryngol Head Neck Surg. 132: 958-966 (2006) |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-182H Fanconi anemia group D2 protein'.
