NB100-265 Dnmt3a antibody
see related secondary antibodiessee all 22 Dnmt3a products
0.1 ml / US$ 435 no delivery possible
Quick Overview
Rabbit anti Dnmt3a
Synonyms
DNMT3A2, M.HsaIIIA, , DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA
Product review
Please read our product review about Dnmt3a : Antibodies to DNA methyltransferases (Dnmt Family).
Product Description
Rabbit anti Dnmt3a , Presentation: Serum. Product is tested for Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Serum |
| Host | Rabbit |
| Catalog Number | NB100-265 |
| Swiss Prot. No. | Q9Y6K1 |
| Quantity | 0.1 ml |
| Price | US$ 435 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet | view  NB100-265.pdf |
Datasheet Extract
| Rabbit Polyclonal anti-DNMT3a | |
| Alternate names | anti-DNMT3A2 antibody; anti-M.HsaIIIA antibody |
| Background | Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT3a) is necessary for the maintenance of the methylation process. |
| Immunogen | This antibody was raised against amino acids 10-118 of
the human DNMT3a protein. Swiss Num.: Q9Y6K1 |
| Applications | immunofluorescence , immunoprecipitation 1:1,000, Western Blot 1:1,000 |
| Specificity | Species: NB 100-265 recognizes human. Other species have not been tested. |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| References | 1. Beaulieu, N., et al. An Essential Role for DNA Methytransferase DNMT3b in Cancer Cell Survival. J. Biol. Chem. 277(31):28176-28181, 2002. (Western blot, human)
2. Robert, MF., et al. DNMT1 is Required to Maintain CpG Methylation and Aberrant Gene Silencing in Human Cancer Cells. Nat. Genet. 33:61-65, 2003. (Western blot, human) 3. Weisenberger, D.J., et al. Identification and characterization of alternately spliced variants of DNA methyltransferase 3a in mammalian cells. Gene. 298:91-99, 2002. (Human/mouse) 4. Reynolds, P. A., Sigaroudinia, M., Zardo, G., Wilson, M. B., Benton, G. M., Miller, C. J., Hong, C., Fridlyand, J., Costello, J. F., and Tlsty, T. D. (2006) Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells, 281, 24790-24802. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-265 Dnmt3a '.
