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NB100-479  Hypoxia-inducible factor 1 alpha antibody

see related secondary antibodies
see all 63 Hypoxia-inducible factor 1 alpha products
0.1 ml / US$ 435 no delivery possible
please contact the manufacturer
Novus Biologicals
Littleton, CO, USA
www.novus-biologicals.com

Quick Overview

Rabbit anti Hypoxia-inducible factor 1 alpha

Synonyms

HIF1A, MOP1, MOP-1, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, Hypoxia-inducible factor 1 alpha,

Product Description

Rabbit anti Hypoxia-inducible factor 1 alpha , Presentation: Aff - Purified. Product is tested for Frozen sections ( C ), Western blot / Immunoblot ( WB )

Properties

ApplicationsFrozen sections ( C ), Western blot / Immunoblot ( WB )
ReactivityMouse ( Ms )
PresentationAff - Purified
HostRabbit
Catalog NumberNB100-479
Swiss Prot. No.Q16665
Quantity0.1 ml
PriceUS$ 435 no delivery possible
DeliveryNot USA/Canada
ManufacturerNovus Biologicals Inc.
Datasheetview PDF-Download
NB100-479.pdf

Datasheet Extract

Rabbit Polyclonal anti-HIF-1 alpha
Alternate namesanti-Hypoxia-inducible factor 1 alpha antibody; anti-HIF1 alpha antibody; anti-ARNT interacting proteinantibody; anti-Hif1a antibody; anti-ARNT interacting protein antibody; anti-HIF-1alpha antibody; anti-Hypoxia inducible factor 1 alpha antibody; anti-Hypoxia inducible factor 1 alpha subunit basic helix antibody
Concentration1.0 mg/ml
BackgroundHypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.

HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF hydroxylases provide insight into hypoxic cell responses, which may be used to help isolate therapeutic targets.
ImmunogenA fusion protein including residues 530-825 of the mouse HIF-1 alpha protein.
Swiss Num.: Q16665
Format
Purification: Immunogen affinity purified
Purity: Immunogen affinity purified
Applicationsimmunohistochemistry 5-10 ug/ml, Western Blot 1:500-1:2000, Immunohistochemistry-Paraffin 5-10 ug/ml, 000
Specificity
Species: This antibody reacts against mouse, rat, human and primate protein. Other species have not yet been determined.
StorageStore at 4C. Do not freeze.

12 Secondary Antibodies

Catalog No.Name / HostPresentationReactivity 
R1364B Rabbit IgG (H&L)  
  Goat Biotin   2 mg / US$ 295
   
R1364F Rabbit IgG (H&L)  
  Goat FITC   2 mg / US$ 285
   
R1364T Rabbit IgG (H&L)  
  Goat TRITC   2 mg / US$ 285
   
R1364TR Rabbit IgG (H&L)  
  Goat Texas Red   2 mg / US$ 295
   
R1364HRP Rabbit IgG (H&L)  
  Goat HRP   2 mg / US$ 295
   
R1364AP Rabbit IgG (H&L)  
  Goat AP   1 mg / US$ 325
   
R1458C2 Rabbit IgG (H&L) multi-species ads.  
  Goat Cy2   1 mg / US$ 445
   
R1458C3 Rabbit IgG (H&L) multi-species ads.  
  Goat Cy3   1 mg / US$ 445
   
R1458C35 Rabbit IgG (H&L) multi-species ads.  
  Goat Cy3.5   1 mg / US$ 445
   
R1458C5 Rabbit IgG (H&L) multi-species ads.  
  Goat Cy5   1 mg / US$ 445
   
R1458C55 Rabbit IgG (H&L) multi-species ads.  
  Goat Cy5.5   1 mg / US$ 445
   
R1427R Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads.  
  Donkey PE   1 ml / US$ 455
   

Click here to see all secondary antibodies for 'NB100-479 Hypoxia-inducible factor 1 alpha'.