Mouse anti Death receptor 5 45B872.1 NB100-56673 - antibody, protein, elisa from Acris Antibodies ...

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0.2 ml / US$ 485 no delivery possible

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Novus Biologicals
Littleton, CO, USA
www.novus-biologicals.com

Mouse anti Death receptor 5 45B872.1

anti-TRAILR2 antibody, TNF-related apoptosis-inducing ligand receptor 2, Tumor necrosis factor receptor superfamily member 10B

Mouse anti Death receptor 5 45B872.1, Presentation: Ascites. Product is tested for Western blot / Immunoblot ( WB )

	Mouse Monoclonal anti-DR5 (45B872.1)
Alternate names	anti-TRAILR2 antibody
Background	Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense1. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently2-8. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
Immunogen	This monoclonal antibody was raised against a peptide corresponding to amino acids 142 to 155 of human DR5 precursor (6,7). *Swiss Num.:* O14763
Format	*Purification:* Ascites *Purity:* Ascites *BufferSystem:* PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Applications	WB
Specificity	*Species:* Human, Mouse Not yet tested in other species.


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