NB100-78391 Fanconi anemia group D2 protein antibody
see related secondary antibodiessee all 16 Fanconi anemia group D2 protein products
0.05 ml / US$ 465 no delivery possible
Quick Overview
Rabbit anti Fanconi anemia group D2 protein
Synonyms
FANCD2, FACD,
Product Description
Rabbit anti Fanconi anemia group D2 protein , Presentation: Aff - Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Isotype | IgG |
| Catalog Number | NB100-78391 |
| Swiss Prot. No. | Q9BXW9 |
| Quantity | 0.05 ml |
| Price | US$ 465 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Polyclonal anti-Fanconi anemia D2 [Ser222] | |
| Alternate names | anti-PD-L2 antibody, anti-PDL2 antibody, anti-B7DC antibody, anti-CD273 antibody |
| Background | Fanconi anemia (also known as Fanconi anemia complementation group D2 (FANCD2)) is a 166 kD member of Fanconi anemia complementation group D. There are multiple isoforms of this nuclear protein including a post-translationally modified form. Activated FANCD2 co-localizes with BRCA1 in ionizing radiation-induced foci and in synaptonemal complexes of meiotic chromosomes. This protein is critical for cellular resistance to DNA cross-linking and cell-cycle arrest after ionizing radiation. DNA damage leads to monoubiquitination of FANCD2 and targeting to nuclear foci. Monoubiquitination occurs during normal cell cycle progression and is required for RAD51 and BRCA1 binding. This protein forms a complex with Fanconi proteins A, C, F, and G. FANCD2 has also been shown to bind to BRCA1, NBS1, and RAD51. The Poly6180 antibody recognizes the phosphorylated human FANCD2 protein (Ser222) and has been shown to be useful for Western blotting. |
| Immunogen | Modified peptide (EILGDS*QHAD) Swiss Num.: Q9BXW9 |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Applications | Western Blot |
| Specificity | Species: Human, reacts with Ser222-phosphorylated FANCD2. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Timmers, C., et al., 2001. Mol. Cell 7:241. 2. Gordon, S., et al., 2003. Blood 102:136. 3. Taniguchi, T., et al., 2002. Blood 100:2414. 4. Nakanishi, K., et al., 2002. Nat. Cell. Biol. 4:913. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-78391 Fanconi anemia group D2 protein'.
