NB100-948 BCL11A / Evi9 / CTIP1 antibody
see related secondary antibodiessee all 8 BCL11A / Evi9 / CTIP1 products
3 x 0.1 mg / please contact our distributor no delivery possible
Quick Overview
Rabbit anti BCL11A / Evi9 / CTIP1
Synonyms
B-cell lymphoma/leukemia 11A, BCL-11A, FLJ10173, BCL11A-XL, BCL11A-L, BCL11A-S, KIAA1809, B-cell CLL/lymphoma 11A, Ecotropic viral integration site 9 protein homolog, zinc finger protein, COUP-TF-interacting protein 1
Product Description
Rabbit anti BCL11A / Evi9 / CTIP1 , Presentation: Aff - Purified. Product is tested for Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | NB100-948 |
| Swiss Prot. No. | Q9H165 |
| Quantity | 3 x 0.1 mg |
| Price | please contact our distributor no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Bcl11a Antibody SuperNovus Pack | |
| Alternate names | anti-Bcl11a antibody, anti-BCL11A antibody, anti-B-cell CLL/Lymphoma 11A antibody, anti-EVI9 antibody, anti-ecotropic viral integration site 9 antibody, anti-CTIP1 antibody, anti-CTIP-1 COUP-TF interacting protein 1 antibody |
| Background | We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The B cell leukemia 11A protein (BCL11A/Evi9/CTIP1) has been implicated in hematopoietic cell development and malignancies. BCL11A is a transcriptional repressor that binds directly to a GC-rich motif and is also recruited to a promoter template via interaction with the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor II. In both cases, BCL11A-mediated transcriptional repression is only minimally reversed by trichostatin A, suggesting the possible lack of involvement of class I or II histone deacetylases. Nonetheless, chromatin immunoprecipitation assays revealed that expression of BCL11A in mammalian cells resulted in deacetylation of histones H3 and/or H4 that were associated with the promoter region of a reporter gene. BCL11A mediated transcriptional repression, as well as deacetylation of histone H3/H4 in BCL11A-transfected cells, was partially reversed by nicotinamide, an inhibitor of class III histone deacetylases such as SIRT1. SIRT1 was found to interact directly with BCL11A and was recruited to the promoter template in a BCL11A-dependent manner leading to transcriptional repression. These findings indicate a role for SIRT1 in transcriptional repression mediated by BCL11A in mammalian cells. |
| Immunogen | See individual datasheets Swiss Num.: Q9H165 |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: Tris-citrate/phosphate pH 7-8 & 0.1% Sodium Azide |
| Applications | Western Blot, immunoprecipitation |
| Specificity | These antibodies are specific for Bcl-11a. Species: Human. Other species not tested. Reactivity with mouse Bcl11a is expected owing to complete identity between this ortholog and human Bcl11a at the site to which the epitope maps. |
| Add. Information | Western Blot, Immunoprecipitation See individual datasheets for dilutions. Other applications have not been tested. |
| Storage | Store at 4C. Do not freeze. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB100-948 BCL11A / Evi9 / CTIP1 '.
