NB110-57026 c-erbB-4 / Her-4 antibody
see related secondary antibodiessee all 27 c-erbB-4 / Her-4 products
0.1 ml / US$ 515 no delivery possible
Quick Overview
Rabbit anti c-erbB-4 / Her-4 E200
Synonyms
p180erbB4, c-erbB4, HER4, Receptor tyrosine-protein kinase erbB-4, Tyrosine kinase-type cell surface receptor HER4
Product Description
Rabbit anti c-erbB-4 / Her-4 E200, Presentation: Purified. Product is tested for Flow cytometry ( F ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Flow cytometry ( F ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ) |
| Presentation | Purified |
| Host | Rabbit |
| Isotype | IgG |
| Clone | E200 |
| Catalog Number | NB110-57026 |
| Swiss Prot. No. | Q15303 |
| Quantity | 0.1 ml |
| Price | US$ 515 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Monoclonal anti-erbB4/HER4 (C-term) (E200) | |
| Alternate names | anti-Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody, anti-ErbB4 antibody, anti-HER 4 antibody, anti-HER4 antibody, anti-MGC138404 antibody, anti-P180erbB4 antibody, anti-Receptor protein tyrosine kinase erbB 4 precursor antibody, anti-Receptor tyrosine protein kinase erbB 4 antibody, anti-Tyrosine kinase type cell surface receptor HER4 antibody, anti-v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody, anti-v erb a erythroblastic leukemia viral oncogene homolog 4 antibody, anti-Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody, anti-Verba erythroblastic leukemia viral oncogene homolog 4 antibody, anti-VERBB2 antibody |
| Background | erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3). |
| Immunogen | Swiss Num.: Q15303 |
| Format | BufferSystem: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Applications | flow cytometry / FACS analysis, immunoprecipitation, Western Blot, Immunocytochemistry |
| Specificity | Species: Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Plowman, G.D., et al. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci U S A. 90: 1746?50 (1993).
2. Elenius, K., et al. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 272: 26761?8 (1997). 3. Garcia, R.A., et al. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A. 97: 3596?601 (2000). |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
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