NB110-57346 P13-Kinase p110 subunit alpha antibody
see related secondary antibodies
0.1 ml / US$ 515 no delivery possible
Quick Overview
Rabbit anti P13-Kinase p110 subunit alpha EP383Y
Synonyms
# caPI3K antibody # MGC142161 antibody # MGC142163 antibody # p110 alpha antibody # p110alpha antibody # Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody # Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody # Phosphatidylinosi,
Product Description
Rabbit anti P13-Kinase p110 subunit alpha EP383Y, Presentation: Aff - Purified. Product is tested for Flow cytometry ( F ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Flow cytometry ( F ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Isotype | IgG |
| Clone | EP383Y |
| Catalog Number | NB110-57346 |
| Quantity | 0.1 ml |
| Price | US$ 515 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Monoclonal anti-P13-Kinase p110 subunit alpha (EP383Y) | |
| Alternate names | anti-caPI3K antibody, anti-MGC142161 antibody, anti-MGC142163 antibody, anti-p110 alpha antibody, anti-p110alpha antibody, anti-Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody, anti-Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody, anti-Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, anti-Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, anti-Phosphoinositide 3 kinase catalytic alpha polypeptide antibody, anti-PI3 kinase p110 subunit alpha antibody, anti-PI3K antibody, anti-PI3KC A antibody, anti-PIK3C A antibody, anti-PIK3CA antibody, anti-PtdIns 3 kinase p110 antibody |
| Background | PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; á, â, ã, and the Ä subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene (3) that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach (4-5). Three ?hot spot? mutations (E542K and E545K; and H1047R) make p110á a potential drug target. |
| Immunogen | Synthetic peptide of human near the C-terminal of P13-K p110 alpha. |
| Format | Purification: Tissue culture supernatant Purity: Tissue culture supernatant BufferSystem: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Applications | immunoprecipitation, Western Blot, Immunocytochemistry |
| Specificity | Species: Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Otsu et al. (1992) Cell 65, 91-104
2. Hiles et al. (1991) Cell 70, 419-429 3. Chang HW, Aoki M, Fruman D, et al. Science 1997;276:1848?50. 4. Depowski PL, Rosenthal SI, Ross JS. Mod Pathol 2001;14:672?6 5. Bose S, Crane A, Hibshoosh H, Mansukhani M, Sandweis L, Parsons R, Hum Pathol 2002;33:405?9. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB110-57346 P13-Kinase p110 subunit alpha'.
