NB110-57350 P13-kinase p85 subunit alpha (C-term) antibody
see related secondary antibodies
0.1 ml / US$ 515 no delivery possible
Quick Overview
Rabbit anti P13-kinase p85 subunit alpha (C-term) EP380Y
Synonyms
# GRB1 antibody # p50 alpha antibody # p55 alpha antibody # p85 alpha antibody # Phosphatidylinositol 3 kinase associated p85 alpha antibody # Phosphatidylinositol 3 kinase regulatory 1 antibody # Phosphatidylinositol 3 kinase regulatory alpha subunit ant,
Product Description
Rabbit anti P13-kinase p85 subunit alpha (C-term) EP380Y, Presentation: Aff - Purified. Product is tested for Flow cytometry ( F ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB )
Properties
| Applications | Flow cytometry ( F ), Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Isotype | IgG |
| Clone | EP380Y |
| Catalog Number | NB110-57350 |
| Quantity | 0.1 ml |
| Price | US$ 515 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Monoclonal anti-P13-kinase p85 subunit alpha (EP380Y) | |
| Alternate names | anti-GRB1 antibody, anti-p50 alpha antibody, anti-p55 alpha antibody, anti-p85 alpha antibody, anti-Phosphatidylinositol 3 kinase associated p85 alpha antibody, anti-Phosphatidylinositol 3 kinase regulatory 1 antibody, anti-Phosphatidylinositol 3 kinase regulatory alpha subunit antibody, anti-Phosphatidylinositol 3 kinase regulatory subunit alpha antibody, anti-Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 antibody, anti-Phosphoinositide 3 kinase regulatory subunit 1 antibody, anti-Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha) antibody, anti-PI3 kinase p85 alpha subunit antibody, anti-PI3 kinase p85 subunit alpha antibody, anti-PI3K antibody, anti-PIK3R1 antibody, anti-PtdIns 3 kinase p85 alpha antibody |
| Background | PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; the regulatory subunit p85 and the catalytic subunit p110 (1-2). In quiescent cells p85 maintains p110 in a low activity state. Upon growth factor stimulation, p85 directly interacts with phosphotyrosine residues of activated growth factor receptors or adaptor proteins leading to activation of p110. p85 exists in two isoforms: p85 , including two short forms termed p50 and p55/AS53 and p85 including short form p55PIK/p55 (3). The p85 adaptor protein uses the inter-SH2 (iSH2) region to bind p110 and employs SH3 and SH2 domains, phosphotyrosine residues, and proline-rich motifs to interact with activated tyrosine kinases such as BCR/ABL and NPM/ALK or adaptor proteins including Shc, c-Cbl, Crk-L, and Gab2 (4-5). |
| Format | BufferSystem: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Applications | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Specificity | Species: Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Otsu et al. (1992) Cell 65, 91-104
2. Hiles et al. (1991) Cell 70, 419-429 3. Inukai et al. (1997) J. Biol. Chem. 272, 7873-7882 4. Klippel, A., J. A. Escobedo, Q. Hu, and L. T. Williams. Mol. Cell. Biol. 13:5560-5566. 5. Jain, S. K., W. Y. Langdon, and L. Varticovski. 1997.Oncogene 14:2217-2228 |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB110-57350 P13-kinase p85 subunit alpha (C-term)'.
