NB120-8400 DFF40 / CAD / DFFB antibody
see related secondary antibodiessee all 31 DFF40 / CAD / DFFB products
0.05 mg / US$ 485 no delivery possible
Quick Overview
Rabbit anti DFF40 / CAD / DFFB
Synonyms
anti-Caspase activated deoxyribonuclease antibody, anti-Caspase activated DNase antibody, anti-Caspase activated nuclease antibody, anti-CPAN antibody, anti-DFF2 antibody, anti-DFF40 antibody, anti-DFFB antibody, anti-DNA fragmentation factor 40 kD beta subunit antibody, DNA fragmentation factor 40kDa beta polypeptide antibody, DNA fragmentation factor subunit beta, DNA fragmentation factor 40 kDa subunit, Caspase-activated deoxyribonuclease, Caspase-activated DNase, Caspase-activated nuclease
Product Description
Rabbit anti DFF40 / CAD / DFFB , Presentation: Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Mouse ( Ms ) |
| Presentation | Purified |
| Host | Rabbit |
| Isotype | IgG |
| Catalog Number | NB120-8400 |
| Swiss Prot. No. | O54788 |
| Quantity | 0.05 mg |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Polyclonal anti-CAD | |
| Alternate names | anti-Caspase activated deoxyribonuclease antibody, anti-Caspase activated DNase antibody, anti-Caspase activated nuclease antibody, anti-CPAN antibody, anti-DFF2 antibody, anti-DFF40 antibody, anti-DFFB antibody, anti-DNA fragmentation factor 40 kD beta subunit antibody, DNA fragmentation factor 40kDa beta polypeptide antibody |
| Background | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation ofchromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD, which stands for caspase activated deoxyribonuclease (1,2). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40 (3,4). Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (1, 2, 5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei (1-4). Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death. |
| Immunogen | Synthetic peptide, corresponding to amino acids 314-329 of Mouse CAD. Swiss Num.: O54788 |
| Format | Purification: IgG purified Purity: IgG purified BufferSystem: PBS with 0.02% sodium azide |
| Applications | WB |
| Specificity | Species: Cross-reacts with Mouse.Not yet tested in other species. |
| References | General / background references:Halenbeck R et al. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45. Curr Biol 8:537-40 (1998). |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB120-8400 DFF40 / CAD / DFFB '.
