NB300-111 Dopamine beta Hydroxylase / DBH antibody
see related secondary antibodiessee all 15 Dopamine beta Hydroxylase / DBH products
30 µg / US$ 485 no delivery possible
Quick Overview
Sheep anti Dopamine beta Hydroxylase / DBH
Synonyms
Dopamine beta-monooxygenase, Soluble dopamine beta-hydroxylase, DOPO, ,
Product review
Please read our product review about Dopamine beta Hydroxylase / DBH : Antibodies to Dopamine, Dopamine- hydroxylase (DBH), Dopamine-transporter and -receptors.
Product Description
Sheep anti Dopamine beta Hydroxylase / DBH , Presentation: Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Monkey ( Mky ), Mouse ( Ms ) |
| Presentation | Purified |
| Host | Sheep |
| Catalog Number | NB300-111 |
| Swiss Prot. No. | P09172 |
| Quantity | 30 µg |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet | view  NB300-111.pdf |
Datasheet Extract
| Sheep Polyclonal anti-Dopamine beta-Hydroxylase | |
| Alternate names | anti-DBH antibody, anti-DBM antibody, anti-Dopamine beta hydroxylase antibody,
anti-Dopamine beta monooxygenase antibody |
| Concentration | 0.3 mg/ml |
| Background | The production of neurotransmitters is controlled by environmental stimuli, which send signals through second messengers and protein kinase pathways. Regulation of gene expression of dopamine beta hydroxylase and tyrosine hydroxylase, two of the catecholamine biosynthetic enzymes, by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis.
Dopamine beta-hydroxylase catalyzes the conversion of dopamine to noradrenaline and is expressed selectively in noradrenergic and adrenergic neurons in the nervous system. The disruption of the DBH gene is thought to cause changes in development and behavior in certain models. Both DBH and the multiple regulatory pathways of DBH are of increasing research in many neurological diseases. |
| Immunogen | C-terminal region of the human form of DBH (DBHC). Swiss Num.: P09172 |
| Format | Purification: IgG purified Purity: IgG purified BufferSystem: PBS with 10% glycerol, 10 mM HEPES (pH 7.2), 20 mM Tris-HCl (pH 7.6), 1 mg/ml bovine serum albumin. |
| Applications | Western Blot 1:1000 |
| Specificity | Species: Human(+++), Monkey(++), Mouse(++), Sheep(--), Canine(--), Rat(--). Immunohistochemical staining was evaluated in the locus coeruleus of formaldehyde-fixed, cryopreserved human and monkey brain. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Swanson, D.J., et al. AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene. J Biol Chem. 273 (37): 24065-74, 1998.
2. Kim, H.S., et al. The cell-specific silencer region of the human dopamine beta-hydroxylase gene contains several negative regulatory elements. J Neurochem. 71(1): 41-50, 1998. 3. Thomas, S.A., and R.D. Palmiter. Examining adrenergic roles in the development, physiology, and behavior through targeted disruption of the mouse dopamine beta-hydroxylase gene. Adv Pharmacol. 42: 57-60, 1998. 4. Sabban, E.L., and B.B. Nankova. Multiple pathways in regulation of dopamine beta-hydroxylase. Adv Pharmacol. 42: 53-56, 1998. |
7 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1456B | Sheep IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 295 | |||||
| R1456F | Sheep IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1456T | Sheep IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1456TR | Sheep IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1456HRP | Sheep IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1456AP | Sheep IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 335 | |||||
| R1433R | Sheep IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB300-111 Dopamine beta Hydroxylase / DBH '.
