NB300-272 Catenin beta pSer33/37 antibody
see related secondary antibodies
0.1 ml / no delivery possible
Quick Overview
Rabbit anti Catenin beta pSer33/37 -
Synonyms
Beta-catenin, Catenin beta-1, CTNNB1, CTNNB, ,
Product review
Please read our product review about Catenin beta pSer33/37: Antibodies to Catenins.
Product Description
Rabbit anti Catenin beta pSer33/37 -, Presentation: Aff - Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | NB300-272 |
| Swiss Prot. No. | P35222 |
| Quantity | 0.1 ml |
| Price | no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet | view  NB300-272.pdf |
Datasheet Extract
| Rabbit Polyclonal anti-Catenin [Ser33/Ser37] | |
| Alternate names | anti-Beta-Catenin antibody, anti-B-Catenin antibody, anti-CTNNB antibody |
| Background | B-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of B-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3B (GSK3B) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of B-catenin. Mutations in components of this phosphorylation regulated process that prevent B-catenin hyperphosphorylation by GSK3B are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002). |
| Immunogen | Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human B-catenin. Swiss Num.: P35222 |
| Format | BufferSystem: 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% glycerol |
| Applications | Western Blot 1:1,000 |
| Specificity | Species: Recognizes human and rat forms of B-catenin. Not tested in other species. The sequence of the immunogen is identical in human, mouse, rat and Xenopus. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | 1. Ding Y, Dale, T (2002) Wnt signal transduction: kinase cogs in a nano-machine. Trends Biochem Sci 27:327-329.
2. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002) Control of B-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108:837-847. 3. Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837-1851. 4. Wang ZH, Vogelstein B, Kinzler KW (2003) Phosphorylation of B-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells. Cancer Res 63:5234-5235. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB300-272 Catenin beta pSer33/37'.