NB300-601 CaSR / PCAR1 antibody
see related secondary antibodiessee all 18 CaSR / PCAR1 products
0.1 ml / US$ 485 no delivery possible
Quick Overview
Rabbit anti CaSR / PCAR1
Synonyms
Calcium Sensing Receptor, GPRC2A, PCAR1, FHH, NSHPT, , Extracellular calcium-sensing receptor, Parathyroid Cell calcium-sensing receptor
Product review
Please read our product review about CaSR / PCAR1 : Antibodies to Calcium Sensing Receptor (CaSR).
Product Description
Rabbit anti CaSR / PCAR1 , Presentation: Aff - Purified. Product is tested for Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Paraffin Sections ( P ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunofluorescence ( IF ), Immunoprecipitation ( IP ), Paraffin Sections ( P ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | NB300-601 |
| Swiss Prot. No. | P41180 |
| Quantity | 0.1 ml |
| Price | US$ 485 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/p ... |
Datasheet Extract
| Rabbit Polyclonal anti-Calcium Sensing Receptor | |
| Alternate names | anti-CaSR antibody, anti-Parathyroid Cell calcium-sensing receptor antibody |
| Background | The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CaSR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). |
| Immunogen | Synthetic peptide: ALAWHSSAYGPDQRAQ, corresponding to amino acids 12-27 of Rat Calcium Sensing Receptor. Swiss Num.: P41180 |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: PBS, 1 mg/ml BSA |
| Applications | immunohistochemistry , immunoprecipitation assay dependent, Western Blot 1:1000, Immunocytochemistry 1:100, Immunohistochemistry-Paraffin 1:100 |
| Specificity | Species: Cross-reacts with Human and Rat. |
| Storage | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| References | McNeil L et al. Functional calcium-sensing receptor expression in ovarian surface epithelial cells. Am J Obstet Gynecol 178:305-13 (1998). <PUBMED:9500491>
McNeil SE et al. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J Biol Chem 273:1114-20 (1998). <PUBMED:9422777> Hebert SC & Brown EM The extracellular calcium receptor. Curr Opin Cell Biol 7:484-92 (1995). <PUBMED:7495567> |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB300-601 CaSR / PCAR1 '.
