NB600-893 UBP43 antibody
see related secondary antibodiessee all 5 UBP43 products
0.1 mg / US$ 555 no delivery possible
Quick Overview
Rabbit anti UBP43
Synonyms
anti-ISG43 antibody; anti-Ubiquitin Specific Protease 18 antibody; anti-USP18 antibody,
Product Description
Rabbit anti UBP43 , Presentation: Aff - Purified. Product is tested for Enzyme Immunoassay ( E )
Properties
| Applications | Enzyme Immunoassay ( E ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Isotype | IgG |
| Catalog Number | NB600-893 |
| Quantity | 0.1 mg |
| Price | US$ 555 no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Novus Biologicals Inc. |
| Datasheet |  http://www.novusbio.com/d ... |
Datasheet Extract
| Rabbit Polyclonal anti-UBP43 | |
| Alternate names | anti-ISG43 antibody, anti-Ubiquitin Specific Protease 18 antibody, anti-USP18 antibody |
| Concentration | 0.9 mg/ml |
| Background | UBP43, also known as ISG43 or USP18 is a member of the deubiquitinating protease family of enzymes, which removes ubiquitin adducts from a broad range of protein substrates. Deletion of the UBP43 gene in mouse leads to a massive increase of ISG15 conjugates in tissues indicating that UBP43 is a major ISG15-specific protease. UBP43 is the first bona fide ISG15-specific protease reported. Both ISG15 and UBP43 genes are known to be strongly induced by interferon, genotoxic stress, and viral infection. Thus UBP43 may be necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. |
| Immunogen | Synthetic peptide: QPRERPRAWDC, corresponding to amino acids 40 - 49 of Human UBP43. |
| Format | Purification: Immunogen affinity purified Purity: Immunogen affinity purified BufferSystem: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7 |
| Applications | ELISA |
| Specificity | Species: Cross-reacts with Human. Not yet tested in other species. |
| References | Tokarz,S., Berset,C., La Rue,J., Friedman,K., Nakayama,K., Nakayama,K., Zhang,D.E. and Lanker,S. (2004) The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase. J. Biol. Chem. 279 (45), 46424-46430. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C. (2003) Human and mouse proteases: a comparative genomic approach. Nat. Rev. Genet. 4 (7), 544-558. Kang,D., Jiang,H., Wu,Q., Pestka,S. and Fisher,P.B. (2001) Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH. Gene 267 (2), 233-242. Schwer,H., Liu,L.Q., Zhou,L., Little,M.T., Pan,Z., Hetherington,C.J. and Zhang,D.E. (2000) Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). Genomics 65 (1), 44-52. Li,X.L., Blackford,J.A., Judge,C.S., Liu,M., Xiao,W., Kalvakolanu,D.V. and Hassel,B.A. (2000) RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. J. Biol. Chem. 275 (12), 8880-8888. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'NB600-893 UBP43'.
