PA029 RANTES (CCL5) antigen
see all 46 RANTES products
5 µg / US$ 255
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse RANTES (CCL5)
Product Description
Mouse RANTES (CCL5)
Properties
| Species | Mouse |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 7.8 kD |
| Catalog Number | PA029 |
| Quantity | 5 µg |
| Price | US$ 255 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA029.pdf |
Datasheet Extract
| Alternate names | Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta
|
| Background | RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). |
| Source | E.coli |
| Format | State: Sterile filtered and lyophilized with no additives Purity: > 98% pure by SDS-PAGE and HPLC analyses Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Centrifuge vial prior to opening. Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or at -20°C for future use. |
| Description | Recombinant murine RANTES is a protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. AASequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS Biological Activity: Determined by its ability to chemoattract total human lymphocyte population and total murine T cell population using a concentration range of 1.0-10.0 ng/ml. Molecular weight: 7.8 kDa |
| Storage | The lyophilized protein is stable at -20°C for one year from date of despatch.
Reconstituted RANTES is stable for 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. |
| References | 1. Yang D, Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses, J Exp Med., 2008, 205(1):79-90.
2. Diaz-Guerra, E., CCL2 Inhibits the Apoptosis Program Induced by Growth Factor Deprivation, Rescuing Functional T Cells. The Journal of Immunology, 2007, 179(11):7352-7. 3. Zelcer, N., Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proceedings of the National Academy of Sciences of the U S A., 2007, 104(25):10601-6. 4. Lunzer, M.M. Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia. The Proceedings of the National Academy of Sciences of the U S A., 2007, 104(14):6061-5. 5. Gwinn, W.M. Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention. Journal of Immunology, 2006, 177(7):4870-9. |
