PA066 I-309 antigen
see all 9 I-309 products
2 µg / US$ 255
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human I-309
Synonyms
I309, TCA3, CCL1,
Product Description
Human I-309
Properties
| Species | Human |
| Purity | >99% |
| Source | E. coli |
| Molecular Weight | 8.5 kD |
| Catalog Number | PA066 |
| Quantity | 2 µg |
| Price | US$ 255 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA066.pdf |
Datasheet Extract
| Recombinant Human I-309 (CCL1) | |
| Alternate names | TCA-3, CCL1 |
| Background | Human I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to other CC chemokines. |
| Source | E.coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) without additives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant Human I-309 is a protein containing 74 amino acid residues. AASequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK Biological Activity: Determined by its ability to chemoattract total human T cell population using a concentration range of 10.0-100.0 ng/ml. Molecular weight: 8.5 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted I-309 should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Cappello, P. CC-Chemokine Ligand 16 Induces a Novel Maturation Program in Human Immature Monocyte-Derived Dendritic Cells. Journal of Immunology, 2006, 177(9):6143-51.
2. Howard OM Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate Blood, 2005, 105(11):4207-14. 3. Hirata T Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus Journal of Biological Chemistry, 2004, 10;279(50):51775-82. 4. Singh UP Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts Journal of Immunology, 2004, 173(9):5509-16. 5. Toshiharu Nakajima Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison Blood, 2002, Vol: 100 (12) pp. 3861-3868. 6. Douglas E. Wright Hematopoietic stem cells are uniquely selective in their migratory response to chemokines J. of Exp. Med., 2002, Vol: 195 (9) pp. 1145-1154. 7. Tiffany HL Amyloid-b Induces Chemotaxis and Oxidant Stress by Acting at Formylpeptide Receptor 2, a G Protein-coupled Receptor Expressed in Phagocytes and Brain* J. Biol Chem., 2001, Vol 276: (26) pp.23645-23652. 8. Campbell JJ Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions Science -- Campbell et al., 2000, 279 (5349) : 381. 9. Bowman EP Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation J. Exp. Med., 2000, 191: pp.1303-1318. 10. Yoshida T Identification of Single C Motif-1/Lymphotactin Receptor XCR1* The Journal of biological Chemistry, 19998, Volume 273. Number 26. Pp.16331-16334. 11. Power CA Cloning and Characterization of a Specific Receptor for the Novel CC Chemokine MIP-3a from Lung Dendritic Cells J.Exp. Med. The Rockefeller University Press, Volume 186, Number 6, pp.825-835 (1997). |