PA067X I-TAC antigen
see all 10 I-TAC products
20 µg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human I-TAC
Synonyms
ITAC CXCL11
Product Description
Human I-TAC ;Is tested for Flow cytometry (F)
Properties
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 8.3 kD |
| Catalog Number | PA067X |
| Quantity | 20 µg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA067X.pdf |
Datasheet Extract
| Recombinant Human I-TAC (CXCL11) | |
| Alternate names | CXCL11, B-R1
|
| Background | I-TAC is a 'non-ELR' CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, or monocytes. |
| Source | E.coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) without additives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg). Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use |
| Description | Recombinant human I-TAC is an 8.3 kDa protein containing 73 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines. AASequence: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF. Biological Activity: Determined by its ability to chemoattract IL-2 activated T-cells using a concentration range of 0.1-10.0 ng/ml. |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted I-TAC should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch |
| References | 1. Miao, Z. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proceedings of the National Academy of Sciences of the U S A.;104(40):15735-40. 10/2/2007
2. Lüttichau, H.R. Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. The Journal of Biological Chemistry.;282(24):17794-805 6/15/2007 3. Burns JM A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med. ;203(9):2201-13 9/4/2006 4. Dagan-Berger M Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11 Blood;107(10):3821-31 5/15/2006 5. Lord GM T-bet is required for optimal proinflammatory CD4+ T-cell trafficking Blood. ; 106(10):3432-9 11/15/2005 6. Howard OM Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate Blood;105(11):4207-14 6/1/2005 7. Foley JF Roles for CXC chemokine ligands 10 and 11 in recruiting CD4+ T cells to HIV-1-infected monocyte-derived macrophages, dendritic cells, and lymph nodes Journal of Immunology; 174(8):4892-900 4/15/2005 8. Ehlert JE Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping Journal of Immunology;173(10):6234-40 11/15/2004 |
