PA117X Oncostatin-M antigen
see all 25 Oncostatin-M products
10 µg / US$ 355
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Oncostatin-M
Synonyms
OSM, Oncostatin-M, Oncostatin M,
Product Description
Human Oncostatin-M
Properties
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 26 kD |
| Catalog Number | PA117X |
| Swiss Prot. No. | P13725 |
| Quantity | 10 µg |
| Price | US$ 355 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA117X.pdf |
Datasheet Extract
| Background | Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. |
| Immunogen | Swiss Num.: P13725 |
| Source | E.coli |
| Format | Purity: Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxinlevel: Less than 0.1 ng per µg (1EU/µg). Reconstitution: Centrifuge the vial prior to opening. Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for one week or at -20°C for future use. |
| Description | Recombinant human Oncostatin M is a 26.0 kDa protein, containing 227 amino acid residues. AASequence: MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR TRPSRKGKRL MTRGQLPR Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < / = 2.0 ng/ml, Specific Activity: > / = 5 x 10e5 units/mg |
| Storage | The lyophilized protein is stable for 1 year from date of despatch at -20°C.
Reconstituted Oncostatin M is stable for 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. |
