PA1219X L-Asparaginase antigen
see all 3 L-Asparaginase products
2500 U / US$ 305
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human L-Asparaginase
Product Description
Human L-Asparaginase ;Is tested for Flow cytometry (F)
Properties
| Presentation | Purified |
| Species | Human |
| Source | E. coli |
| Molecular Weight | 32 kD |
| Catalog Number | PA1219X |
| Quantity | 2500 U |
| Price | US$ 305 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1219X.pdf |
Datasheet Extract
| L-Asparaginase | |
| Background | L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E. coli., which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukaemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase may be of value in managing the disease.
The rationale behind asparaginase is that it takes advantage of the fact that ALL cell sare unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acidand ammonia. This deprives the leukemic cell of circulating asparagine. |
| Source | E. coli |
| Format | State: Sterile filtered white lyophilized powder containing no additives Purity: Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Description | L-Asparaginase containing 303 amino acids. Biological Activity: One IU of L- Asparaginase is defined as that amount of enzyme required to generate 1 µmol of ammonia per minute at pH 7.3 and 37 °C. Specific Activity: 250,000 IU/mg Molecular weight: 31731 Dalton |
| Add. Information | One unit of enzyme catalyzes hadrylazation of 10 nanomoles of dUTP to dUMP in one hour at 85 Centigrade. |
| Storage | The enzyme is stable for two years when stored at â??20 °C, 2 weeks at 4 °C. Avoid repeated freezing and thawing.
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