PA1230XC MAPK9 antigen
see all 27 MAPK9 products
1 mg / please contact our distributor
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human MAPK9
Synonyms
MAPK-9, JNK-55, JNK2, PRKM9, , Mitogen-activated protein kinase 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2
Product review
Please read our product review about MAPK9: Antibodies to MAP-Kinases.
Product Description
Human MAPK9
Properties
| Presentation | Purified |
| Species | Human |
| Purity | >85% |
| Source | E. coli |
| Molecular Weight | 48 kD |
| Catalog Number | PA1230XC |
| Swiss Prot. No. | P45984 |
| Quantity | 1 mg |
| Price | please contact our distributor |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA1230XC.pdf |
Datasheet Extract
| Recombinant//Human JUN N-terminal Kinase alpha | |
| Alternate names | Mitogen-activated protein kinase 9, EC 2.7.11.24, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, JNK-55, JNK2, JNK2A, JNK2B, PRKM9, JNK-55, JNK2BETA, p54aSAPK, JNK2ALPHA, MAPK9, JUN N-terminal Kinase 2 alpha 1, JNK2a-1. |
| Background | JUN N-terminal Kinase 2is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Immunogen | Swiss Num.: P45984 |
| Source | E. coli |
| Format | State: Sterile Filtered clear solution Purity: Greater than 85% as determined by SDS-PAGE. Mass spectrometry of tryptic digest products for identity determination. BufferSystem: 25 mM HEPES at pH 8.0, 150 mM NaCl, 2 mM DTT and 10 % glycerol |
| Description | JNK2is a soluble protein that is activated in response to cellular stress, radiation and growth factors. JNK2 binds to the amino terminal activation domains of c-jun or ATF2 regulating AP-1 transcriptional activity.
This protein is the full-length form of the protein with a C-terminal His-tag (His-tag on COOH terminus). AASequence: MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP FQNQTHAKRAYRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH MELDHERMSY LLYQMLCGIKHLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF MMTPYVVTRY YRAPEVILGM GYKENVDIWSVGCIMGELVK GCVIFQGTDH IDQWNKVIEQ LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIFPSESERDKIK TSQARDLLSK MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIEEWKELIYKEV MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS TEQTLASDTD SSLDASTGPLEGCRGGGSHH HHHH Biological Activity: Activity is approximately 200 units/mg. A certificate of analysis is provided, stating the enzymatic activity for each production lot. 1.0 unit of activity is defined as the amount of enzyme required to catalyze the transfer of nmole of phosphate from ATP to to a protein substrate per minute at 30 ºC. Molecular weight: 48 kDa |
| Storage | Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. |