PA123X RANTES (CCL5) antigen
see all 46 RANTES products
20 µg / US$ 355
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human RANTES (CCL5)
Product Description
Human RANTES (CCL5)
Properties
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 7.8 kD |
| Catalog Number | PA123X |
| Quantity | 20 µg |
| Price | US$ 355 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA123X.pdf |
Datasheet Extract
| Alternate names | Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta
|
| Background | RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). |
| Source | E. coli |
| Format | State: Sterile filtered and lyophilized (without additives) Purity: > 98% pure by SDS-PAGE and HPLC analyses Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Centrifuge the vial prior to opening. Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Recombinant human RANTES is a protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. AASequence: SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS Biological Activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml. Molecular weight: 7.8 kDa |
| Storage | The lyophilized protein is stable at -20°C for one year from date of despatch.
Reconstituted RANTES is stable for 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. |
| References | 1. Bristow, C.L. NF-{kappa}B Signaling, Elastase Localization, and Phagocytosis Differ in HIV-1 Permissive and Nonpermissive U937 Clones. The Journal of Immunology.;180(1):492-9 1/1/2008
2. Hamdan, F.F. Unraveling g protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta -arrestins and AP-2. The Journal of Biological Chemistry.;282(40):29089-100. 10/5/2007 3. Mateo T, A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles Blood. ;110(6):1895-902 9/15/2007 4. Schröder, C. CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates. The Journal of Immunology.;179(4):2289-99 8/15/2007 5. Ponte AL The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities Stem Cells. ;25(7):1737-45 7/1/2007 6. Yurchenko E CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence J Exp Med. ;203(11):2451-60 10/30/2006 7. de Nadai P CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo J Invest Dermatol. ;126(9):2057-64 9/1/2006 8. Zhang N Adenosine A2a receptors induce heterologous desensitization of chemokine receptors. Blood.;108(1):38-44 7/1/2006 9. Zaph C. Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth. Journal of Immunology;177(1):511-8. 7/1/2006 10. Hagnerud S Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration J Immunol.;176(10):5772-8 5/15/2006 11. Douville RN Human metapneumovirus elicits weak IFN-gamma memory responses compared with respiratory syncytial virus J Immunol.;176(10):5848-55 5/15/2006 12. Maeda K Structural and Molecular Interactions of CCR5 Inhibitors with CCR5. J Biol Chem.;281(18):12688-98 5/5/2006 13. Honczarenko M Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors Stem Cells. ;24(4):1030-41 4/1/2006 |
