PA129 Thymus Expressed Chemokine (TECK) antigen
see all 7 Thymus Expressed Chemokine products
5 µg / US$ 255
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Thymus Expressed Chemokine (TECK)
Synonyms
CCL25,
Product Description
Human Thymus Expressed Chemokine (TECK)
Properties
| Species | Human |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 14.2 kD |
| Catalog Number | PA129 |
| Quantity | 5 µg |
| Price | US$ 255 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA129.pdf |
Datasheet Extract
| Alternate names | Thymus Expressed Chemokine, CCL25
|
| Background | TECK is a CC chemokine, specifically expressed by thymic stromal cells, and signals through the CCR9 receptor. TECK is chemotactic towards activated macrophages, thymocytes and dendritic cells. |
| Source | E.coli |
| Format | State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) without additives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. ( |
| Description | Recombinant human TECK is a protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines. AASequence: QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSRKNVSLL ISANSGL Biological Activity: Determined by its ability to chemoattrract human monocytes using a concentration range of 1.0-10.0 ng/ml. Molecular weight: 14.2 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted TECK should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Lüttichau, H.R. Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. The Journal of Biological Chemistry, 2007, 282(24):17794-805.
2. Alejo A A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus Proc Natl Acad Sci U S A., 2006, 103(15):5995-6000. 3. Honczarenko M Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors Stem Cells, 2006, 24(4):1030-41. 4. Howard OM Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate Blood, 2005, 105(11):4207-14. 5. Singh, S. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clinical Cancer Research, 2004, 10(24):8743-50. 6. Eric J. Kunkel CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells J. of Clinical Invest., 2003, Vol: 111 (7) pp. 1001-1010. 7. Hans R. Luttichau A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6 J. Bio. Chem., 2003, Vol: 278 (13) pp. 10928-10933. 8. James J. Campbell Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire Immunology, 2001, 166 pp.6477-6482. 9. Schweickart VL CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines* The Journal of Biological Chemistry, 2000, Volume 275. Number 13. Pp.9550-9556. 10. Kunkel EJ Lymphocyte CC Chemokine Receptor 9 and Epithelial Thymus-expressed Chemokine (TECK) Expression Distinguish the Small Intestinal Immune Compartment: Epithelial Expression of Tissue-specific Chemokines as an Organizing Principle in Regional Immunity J. Exp. Med., 2000, 192: pp.761-768. |
