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Product Description for TGF-beta-1 (TGFB1)
Latency-associated peptide
Properties for TGF-beta-1 (TGFB1)
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 5 µg |
| Shipping to | Worldwide |
| PDF datasheet | view  |
| Source | CHO cells |
| Species (Protein) | Human |
Datasheet Extract
| Product Type | Proteins |
| Description | Specific activity: >/= 2 x 10e7 units/mg |
| Biological activity: The ED50 as determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is | |
| AA Sequence: ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS | |
| Description: Recombinant human TGF-β1 is a protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. | |
| Synonyms | Transforming growth factor beta-1, TGFB, LAP |
| Swiss Prot Num | P01137 |
| Format | Reconstitution: Restore in 10 mM Citric Acid pH 3.0 to a concentration of 0.1-1.0 mg/ml. This solution can then be stored at room temperature or at 2-8°C for 1 month. It is recommended that further dilutions be made in PBS containing 2 mg/ml Albumin and stored at -20°C for future use. |
| Purity: > 98% | |
| Buffer System: 10 mM Sodium Citrate, pH 3.5 without preservatives. | |
| Endotoxin level: < 0.1 ng per µg (1 EU/µg) | |
| Purity: pure by SDS-PAGE gel and HPLC analyses. | |
| State: Lyophilized, Sterile filtered purified protein. | |
| Add. information | Centrifuge the vial prior to opening. |
| Background | The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. |
