PA202 CD254 / TNFSF11 / TRANCE antigen
see all 39 CD254 / TNFSF11 / TRANCE products
2 µg / US$ 255
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse CD254 / TNFSF11 / TRANCE
Synonyms
TNFSF11, OPGL, RANKL, TRANCE, , Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, Tumor necrosis factor ligand superfamily member 11
Product Description
Mouse CD254 / TNFSF11 / TRANCE
Properties
| Species | Mouse |
| Purity | >98% |
| Source | E. coli |
| Molecular Weight | 19.4 kD |
| Catalog Number | PA202 |
| Swiss Prot. No. | O35235 |
| Quantity | 2 µg |
| Price | US$ 255 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA202.pdf |
Datasheet Extract
| Alternate names | soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)
|
| Background | RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. |
| Immunogen | Swiss Num.: O35235 |
| Source | E.coli |
| Format | State: Sterile filtered, Lyophilized Purity: Greater than 98% by SDS-PAGE and HPLC analyses. BufferSystem: 5 mM Tris, pH 7.6, + 75 mM NaCl Endotoxinlevel: Less than 0.1 ng per µg (1EU/µg). Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for one week or at -20°C for future use. |
| Description | Recombinant murine sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).
AASequence: PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID Biological Activity: Measured by its ability to induce osteoclast formation in RAW264.7 cells using a concentration of 5.0-10.0 ng/ml. |
| Storage | The lyophilized protein is stable for one year from despatch at -20°C.
Reconstituted sRANKL is stable for 3 months when stored in working aliquots with a carrier protein at -20°C. |
