PA269 Activin A antigen
see all 12 Activin A products
1 µg / US$ 255
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Human Activin A
Product Description
Human Activin A
Properties
| Species | Human |
| Purity | >95% |
| Source | High-5 Insect cells |
| Molecular Weight | 26 kD |
| Catalog Number | PA269 |
| Quantity | 1 µg |
| Price | US$ 255 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  PA269.pdf |
Datasheet Extract
| Background | Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin.
*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc. |
| Source | (BTI-Tn-5B1-4) High-5 Insect Cells* |
| Format | State: Lyophilized purified fraction (>95% pure by SDS-PAGE and HPLC analyses) with no additives. Endotoxinlevel: < 0.1 ng per µg (1EU/µg) Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use. |
| Description | Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues. AASequence: GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS. Biological Activity: The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is < 2 ng/ml. Specific Activity: > 5 x 10e5 units/mg Molecular weight: 26 kDa |
| Add. Information | Centrifuge the vial prior to opening! |
| Storage | Store the lyophilized protein at -20°C.
Reconstituted Human Activin A should be stored in working aliquots at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1.Vallier L, Conditional gene expression in human embryonic stem cells Stem Cells, 2007, 25(6):1490-1497.
2. Burridge PW, Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells, 2007, 25(4):929-938. 3. Qin, H. Regulation of Apoptosis and Differentiation by p53 in Human Embryonic Stem Cells. Journal of Biological Chemistry, 2007, 282(8):5842-5852. 4. Hasegawa K A method for the selection of human embryonic stem cell sublines with high replating efficiency after single-cell dissociation Stem Cells, 2006, 24(12):2649-2660. |
