SM7024P Decoy receptor 3 antibody
see related secondary antibodiessee all 20 Decoy receptor 3 products
0.1 mg / US$ 425
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Mouse anti Decoy receptor 3 37A565
Synonyms
TNFRSF6B, DCR3, TR6, DCR-3, TR-6, Decoy receptor for Fas ligand, M68, , Tumor necrosis factor receptor superfamily member 6B
Product Description
Mouse anti Decoy receptor 3 37A565, Presentation: Purified. Product is tested for Western blot / Immunoblot ( WB )
Properties
| Applications | Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Purified |
| Host | Mouse |
| Isotype | IgG |
| Clone | 37A565 |
| Catalog Number | SM7024P |
| Swiss Prot. No. | O95407 |
| Quantity | 0.1 mg |
| Price | US$ 425 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SM7024P.pdf |
Datasheet Extract
| Concentration | 0.5 mg/ml |
| Background | Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand (FasL) of the TNF family through their death domain containing receptors, TNFR1 and Fas (also known as CD95 or Apo-1). Recently, Pitti et al., 1998 have identified a molecule that can bind to FasL and block its binding to Fas (1). This molecule called, decoy receptor 3 (DcR3), is generally amplified in a number of lung and colon carcinomas suggesting that certain tumors may escape FasL-dependent cell death by expressing a decoy receptor that blocks FasL (1,2). An identical molecule was isolated by Yu et al, 1999 that also binds to FasL and another cellular ligand, LIGHT (herpes virus entry mediator (HVEM)-L) (3,4). It has been shown that LIGHT induces apoptosis of various tumor cells that express both lymphotoxinb receptor and HVEM/TR2 receptors. DcR3/TR6 is constitutively expressed in lung tissue, tumor cells and in endothelial cells (1,3). Like other members of TNFR superfamily, DcR1, DcR2 and OPG, DcR3/TR6 may act as an inhibitor of signaling through TNF family members, FasL and LIGHT. However, unlike DcR1 and DcR2, which are membrane-associated proteins, DcR3 is directly secreted into the extracellular space. |
| Immunogen | A full-length recombinant protein of human DcR3 Swiss Num.: O95407 |
| Format | State: Liquid Ig fraction Purification: Protein G chromatography BufferSystem: PBS containing 0.02% sodium azide |
| Applications | Western blot analysis: 2.0 - 4.0 µg/ml.
Positive control: Jurkat (a 34 kDa band is observed). |
| Specificity | This antibody is specific for DcR3. Species: Human. |
| Storage | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. |
| References | 1. Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, et al. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 396: 699-703 (1998).
2. Green DG. Apoptosis: Death deceiver. Nature 396: 629-630 (1998). 3. Yu, K-Y, Kwon B, Ni J, Zhai Y, Ebner R, and Kwon BS. A newly identified member of tumor factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptois. J. Biol. Chem. 274: 13733-13736 (1999). 4. Mauri DN, Ebner R, Kochel KD, Montogomery RI, Cheung TC, Yu G-L, et al. LIGHT, a new member of TNF superfamily, and lymphotoxina are ligands for herpesvirus entry mediator. Immunity 8: 21-30 (1998). |
| Pictures | Western blot analysis of 30 µg of total cell lysate from Jurkat cells with SM7024P at 2 µg/ml.
|
14 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / US$ 305 | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / US$ 285 | |||||
| R1253T | Mouse IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / US$ 285 | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / US$ 295 | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / US$ 315 | |||||
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / US$ 325 | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1457C35 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1457C55 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Bov, Eq, Hu, Rb, Rt, Sh | ||||||
| Goat | PE | 1 ml / US$ 455 | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment ads. to Hu serum proteins | ||||||
| Rabbit | PE | 1 ml / US$ 455 | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SM7024P Decoy receptor 3 '.
