SP4077P Bradykinin B1 Receptor / BDKRB1 (Cytoplasm. Dom) antibody
see related secondary antibodiessee all 8 Bradykinin B1 Receptor / BDKRB1 products
50 µg / no delivery possible
please contact the manufacturer
Quick Overview
Rabbit anti Bradykinin B1 Receptor / BDKRB1 (Cytoplasm. Dom) -
Synonyms
BK-1 Receptor, B1BKR, B1R, BKB1R, BKR1, , B1 Bradykinin Receptor
Product review
Please read our product review about Bradykinin B1 Receptor / BDKRB1 (Cytoplasm. Dom): Antibodies to desArg9-Bradykinin and Bradykinin Receptors.
Product Description
Rabbit anti Bradykinin B1 Receptor / BDKRB1 (Cytoplasm. Dom) -, Presentation: Aff - Purified. Product is tested for Paraffin Sections ( P )
Properties
| Applications | Paraffin Sections ( P ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP4077P |
| Swiss Prot. No. | P46663 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP4077P.pdf |
Datasheet Extract
| Polyclonal Antibody to Bradykinin B1 Receptor | |
| Alternate names | BKB1R, BKR1, BRADYB1, B1BKR, b1 bradykinin receptor, bdkrb1, bk b1 receptor, bk-1 receptor, bkr1, bradykinin receptor b1, bradykinin receptor, beta, kinin b1 receptor |
| Concentration | 1.0 mg/ml |
| Background | Bradykinin Receptor B1 (BKB1) has been implicated in inflammation and nociception. BKB1 receptor is rapidly induced under many inflammatory conditions such as colitis and hyperalgesia, allergic rhinitis, and inflammation. In vitro studies have implicated lipopolysaccharide, interleukins, and interferon as effectors in the rapid induction of BKB1 receptor expression. BKB1 receptor-deficient mice are healthy, fertile, and normotensive but show blunted response to lipopolysaccharide-induced hypotension, reduced migration into inflamed tissues by polymorphonuclear leukocytes, and reduced activity-dependent facilitation of a spinal nociceptive reflex.
Bradykinin B1 receptor is generally only minimally expressed under normal physiological conditions, but the expression is induced rapidly under pathologic conditions such as ischemia, atheromatous disease, or exposure to inflammatory cytokines. Expression has been reported in brain, colon, kidney, lung, nasal mucosa, pancreas, prostate, skin, spinal cord, and vessel. ESTs have been isolated from normal human connective tissue libraries and in human kidney and skin cancer libraries. |
| Immunogen | Synthetic peptide - KLH conjugated
Epitope: 3rd cytoplasmic domain of human Genename: BDKRB1 Swiss Num.: P46663 Remarks: The immunizing peptide shows 68 % identity (87 % similarity) with mouse and 75 % identity (87 % similarity) with rat. |
| Format | State: Liquid Ig fraction Purification: Peptide immunogen affinity column BufferSystem: PBS, pH 7.7, containing 0.01% sodium azide |
| Applications | Immunohistochemistry with formalin fixed paraffin embedded tissues: 5-9 µg/ml
Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. |
| Specificity | Reacts with Bradykinin B1 Receptor 1 (family: GPCR, subfamily:Bradykinin) Species: Human. |
| Add. Information | This product was originally produced by MBL International. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -70°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||