SP4124P Endothelin B Receptor / EDNRB antibody
see related secondary antibodiessee all 15 Endothelin B Receptor / EDNRB products
50 µg / no delivery possible
please contact the manufacturer
Quick Overview
Rabbit anti Endothelin B Receptor / EDNRB
Synonyms
ET-B, ETRB, , Endothelin Receptor B, Endothelin receptor Non-selective type
Product review
Please read our product review about Endothelin B Receptor / EDNRB: Antibodies to Endothelin & Endothelin receptors.
Product Description
Rabbit anti Endothelin B Receptor / EDNRB , Presentation: Aff - Purified. Product is tested for Immunofluorescence ( IF ), Paraffin Sections ( P ), Western blot / Immunoblot ( WB )
Properties
| Applications | Immunofluorescence ( IF ), Paraffin Sections ( P ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP4124P |
| Swiss Prot. No. | P24530 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP4124P.pdf |
Datasheet Extract
| Polyclonal Antibody to Endothelin B Receptor (EDNRB) | |
| Alternate names | ET-B, ETB, ETRB, HSCR, HSCR2, ABCDS, ednrb, endothelin receptor type b, et-b receptor, et-b-r, ET-RB, etb receptor, etb-svr, etrb, hscr2 |
| Concentration | 1.0 mg/ml |
| Background | The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct.
The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. |
| Immunogen | Synthetic peptide - KLH conjugated
Epitope: N-terminal extracellular domain of human Genename: EDNRB Swiss Num.: P24530 Remarks: The immunizing peptide shows 21 % identity (21 % similarity) with mouse and 21 % identity (21 % similarity) with rat. |
| Format | State: Liquid purified IgG fraction Purification: Peptide immunogen affinity column BufferSystem: PBS, pH 7.7, containing 0.09% Sodium Azide as preservative |
| Applications | Western Blot.
Immunocytochemistry. Immunohistochemistry on paraffin embedded sections: 4-11 µg/ml Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. |
| Specificity | Detects Endothelin B Receptor (Family: GPCR; Subfamily: Endothelin) Species: Human. |
| Add. Information | This product was originally produced by MBL International. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20 to -70°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Pictures | Figure 1. Immunohistochemical staining of Adrenal (Medulla) using anti-EDNRB antibody SP4124P. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP4124P Endothelin B Receptor / EDNRB'.
