SP4393P mGluR1 / GRM1 (extracell. Dom.) antibody
see related secondary antibodiessee all 14 mGluR1 / GRM1 products
50 µg / no delivery possible
please contact the manufacturer
Quick Overview
Rabbit anti mGluR1 / GRM1
Synonyms
Metabotropic glutamate receptor 1, GPRC1A, MGLUR1, ,
Product review
Please read our product review about mGluR1 / GRM1 : Metabotropic Glutamate Receptor Antibodies.
Product Description
Rabbit anti mGluR1 / GRM1 , Presentation: Aff - Purified. Product is tested for Paraffin Sections ( P )
Properties
| Applications | Paraffin Sections ( P ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP4393P |
| Swiss Prot. No. | Q13255 |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP4393P.pdf |
Datasheet Extract
| Alternate names | GRM1A, MGLU1, MGLUR1, MGLUR1A, GPRC1A, glutamate receptor, metabotropic 1, grm1, MGLU1 RECEPTOR, mglur1 |
| Concentration | 1 mg/ml |
| Background | The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.
mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1). |
| Immunogen | Synthetic peptide - KLH conjugated
Epitope: N-terminal extracellular domain of human Genename: GRM1 Swiss Num.: Q13255 Remarks: The immunizing peptide shows 94 % identity (100 % similarity) with mouse and 94 % identity (100 % similarity) with rat. |
| Format | State: Liquid Ig fraction Purification: Peptide immunogen affinity column BufferSystem: PBS, pH 7.7, containing 0.01% sodium azide |
| Applications | Immunohistochemistry with formalin fixed paraffin embedded tissues: 17 µg/ml
Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. |
| Specificity | Reacts with Metabotropic Glutamate Receptor 1
(family: GPCR, subfamily: Metabotropic glutamate) Species: Human. |
| Add. Information | This product was originally produced by MBL International. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -70°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Pictures | Immunohistochemical staining of Brain (Neurons and glia) using anti- GRM1 antibody SP4393P |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP4393P mGluR1 / GRM1 '.
