Double click on above image to view full picture
SP4634P Calcium Sensing Receptor (CaSR) (NT extracell. Dom.) antibody
see related secondary antibodies
50 µg / no delivery possible
please contact the manufacturer
Quick Overview
Rabbit anti Calcium Sensing Receptor (CaSR) (NT extracell. Dom.) -
Synonyms
CASR GPRC2A PCAR1
Product review
Please read our product review about Calcium Sensing Receptor (CaSR) (NT extracell. Dom.): Antibodies to Calcium Sensing Receptor (CaSR).
Product Description
Rabbit anti Calcium Sensing Receptor (CaSR) (NT extracell. Dom.) -, Presentation: Aff - Purified. Product is tested for Paraffin Sections ( P )
Properties
| Applications | Paraffin Sections ( P ) |
| Reactivity | Human ( Hu ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP4634P |
| Quantity | 50 µg |
| Price | no delivery possible |
| Delivery | Not USA/Canada |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP4634P.pdf |
Datasheet Extract
| Polyclonal Antibody to Human Calcium-Sensing Receptor CASR | |
| Alternate names | FHH, FIH, GPRC2A, HHC, HHC1, MGC138441, NSHPT, PCAR1, CAR, ca sensing receptor, ca2+ sensing receptor, extracellular calcium-sensing receptor, hhc1, nshpt, parathyroid ca2+ sensing receptor 1, pcar1 |
| Concentration | 1 mg/ml |
| Background | CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.
CASR has been documented in bone marrow, brain, breast (mostly cancer), colon, kidney, parathyroid, skin, stomach, and thyroid. ESTs have been isolated from normal kidney and gallbladder, in addition to parathyroid cancer libraries. |
| Immunogen | Synthetic peptide - KLH conjugated
Epitope: N-terminal extracellular domain of human Genename: CASR Remarks: The immunizing peptide shows 75 % identity (80 % similarity) with mouse and 75 % identity (80 % similarity) with rat. |
| Format | State: Liquid Ig fraction Purification: Peptide immunogen affinity column BufferSystem: PBS, pH 7.7, containing 0.01% sodium azide |
| Applications | Immunohistochemistry with formalin fixed paraffin embedded tissues: 5 µg/ml
Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. |
| Specificity | Reacts with Calcium-Sensing Receptor CASR
(family: GPCR, subfamily: Calcium-sensing) Species: Human. |
| Add. Information | This product was originally produced by MBL International. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -70°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Pictures | Immunohistochemical staining of Parathyroid using anti- CASR antibody SP4634P |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 170,00 € | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160,00 € | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160,00 € | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / 170,00 € | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170,00 € | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 200,00 € | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / 320,00 € | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / 320,00 € | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / 320,00 € | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / 320,00 € | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / 320,00 € | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / 330,00 € | |||||
