SP5151P AGER / RAGE antibody
see related secondary antibodiessee all 25 AGER / RAGE products
0.1 mg / US$ 455
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti AGER / RAGE
Synonyms
Receptor for Advanced Glycosylation End products, , Advanced glycosylation end product-specific receptor, AGE Receptor, MGC22357
Product review
Please read our product review about AGER / RAGE: AGE – Advanced Glycation End Products.
Product Description
Rabbit anti AGER / RAGE , Presentation: Aff - Purified. Product is tested for Frozen sections ( C ), Western blot / Immunoblot ( WB )
Properties
| Applications | Frozen sections ( C ), Western blot / Immunoblot ( WB ) |
| Reactivity | Mouse ( Ms ), Rat ( Rt ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP5151P |
| Swiss Prot. No. | Q15109 |
| Quantity | 0.1 mg |
| Price | US$ 455 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP5151P.pdf |
Datasheet Extract
| Background | The receptor for advanced glycation endproducts (RAGE) is a member of the Immunoglobin superfamily of cell surface markers. This protein is able to interact with many molecules including: advanced glycation endproducts (AGE), amphoterin, and ligands.
Research has shown that the accumulation of RAGE ligands in the biological system (endothelium mononuclear phagocytes, neurons and smooth muscle cells) can lead to destructive tissue diseases such as diabetic retinopathy, amyloidoses, tumors and inflammation disorders. |
| Immunogen | Synthetic peptide corresponding to residues 362-380 of rat RAGE. Swiss Num.: Q15109 AA Sequence: C(362) W R K R Q P R (R/L) E E R K A P E S Q E D(380) Remarks: This sequence is 100% conserved in mouse and 70% conserved in human. |
| Format | State: Liquid purified Ig fraction Purification: Epitope affinity chromatography BufferSystem: PBS containing 1.0 mg/ml BSA and 0.05% sodium azide |
| Applications | Immunohistochemistry on frozen sections (1-2 µg/ml): Immunohistochemical staining of RAGE in transgenic mouse retina results in staining of the retinal pigmented epithelium and photo receptor cell layers.
Western blotting (1 µg/ml): By Western blot, this antibody detects two bands in the 45 kDa range representing the RAGE protein pre and post-glycosylation in mouse lung extract. This antibody also detects an ~25 kDa protein that is believed to be proteolytic degradation product. |
| Specificity | This antibody detects receptor for advanced glycation endproducts (RAGE).
Species: Rat, mouse. |
| Add. Information | The immunizing peptide is available for use in neutralization and control experiments (SP5151CP). |
| Storage | Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | Nature Biotechnology 22(8): 985-992, 2004. |
| Pictures | Figure 1 illustrates immunohistochemical staining of RAGE from transgenic mouse retinas using SP5151P. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP5151P AGER / RAGE'.
