SP5223P CaMK IV / CaMKGR antibody
see related secondary antibodiessee all 17 CaMK IV / CaMKGR products
0.1 mg / US$ 455
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti CaMK IV / CaMKGR
Synonyms
CAMK4, CAMK-4, CAMKIV, CAM kinase-GR, , Calcium/calmodulin-dependent protein kinase type IV
Product review
Please read our product review about CaMK IV / CaMKGR: Antibodies to Calmodulin and CaM-kinases.
Product Description
Rabbit anti CaMK IV / CaMKGR , Presentation: Aff - Purified. Product is tested for Frozen sections ( C ), Western blot / Immunoblot ( WB )
Properties
| Applications | Frozen sections ( C ), Western blot / Immunoblot ( WB ) |
| Reactivity | Canine ( Can ), Human ( Hu ), Mouse ( Ms ), Prim ( Prim ), Rat ( Rt ), Xenopus ( Xen ), Arabidopsis ( Arabidopsis ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP5223P |
| Swiss Prot. No. | Q16566 |
| Quantity | 0.1 mg |
| Price | US$ 455 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP5223P.pdf |
Datasheet Extract
| Concentration | 1.0 mg/ml |
| Background | CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C/EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids. |
| Immunogen | Synthetic Peptide: V(127) E K G Y Y S E R D A A D A V K Q(143) C corresponding to amino acid residues 127-143 from mouse CaMKIV. Swiss Num.: Q16566 Remarks: This sequence is 94% conserved in rat and human CaMKIV. This peptide (SP5223CP) is available for use in Neutralization and Control experiments. |
| Format | State: Liquid purified IgG fraction. Purification: Epitope affinity chromatography. BufferSystem: PBS containing 1 mg/ml BSA and 0.05% sodium azide as preservative. |
| Applications | Western Blot: 0.5 µg/ml, detects an ~55 kDa protein representing CaMKIV in HeLa cell lysate. Immunohistochemistry on frozen sections: 1 µg/ml. |
| Specificity | This antibody detects CaM kinase IV (CaMKIV) from arabidopsis, canine, human, mouse, primate, rat tissues and xenopus oocyte samples. |
| Storage | Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Biochim. Biophys. Acta, 1448:183-189, 1998.
2. Molecular Pharmacology Fast Forward Feb 2005 doi:10.1124/mol.104.007872 . |
| Pictures | Figure 1. Western blot of CaMKIV in rat brain extract using SP5223P. |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP5223P CaMK IV / CaMKGR'.
