SP6247P CD262 / TNFRSF10B / KILLER (388-407) antibody
see related secondary antibodiessee all 53 CD262 / TNFRSF10B / KILLER products
50 µg / US$ 325
NOVUS BIOLOGICALS
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
PO Box 802 Littleton, CO 80160, USA
E-Mail: novus@novus-biologicals.com
Homepage: http://www.novus-biologicals.com
Quick Overview
Rabbit anti CD262 / TNFRSF10B / KILLER
Synonyms
TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, Death receptor 5, , TNF-related apoptosis-inducing ligand receptor 2, Tumor necrosis factor receptor superfamily member 10B
Product Description
Rabbit anti CD262 / TNFRSF10B / KILLER , Presentation: Aff - Purified. Product is tested for Paraffin Sections ( P ), Western blot / Immunoblot ( WB )
Properties
| Applications | Paraffin Sections ( P ), Western blot / Immunoblot ( WB ) |
| Reactivity | Human ( Hu ), Mouse ( Ms ) |
| Presentation | Aff - Purified |
| Host | Rabbit |
| Catalog Number | SP6247P |
| Swiss Prot. No. | Q9ER62 |
| Quantity | 50 µg |
| Price | US$ 325 |
| Delivery | Worldwide |
| Manufacturer | Acris Antibodies GmbH |
| Datasheet | view  SP6247P.pdf |
Datasheet Extract
| Alternate names | Apo2, TRAIL-R2, TRICK2, KILLER |
| Concentration | 0.2 mg/ml |
| Background | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB. |
| Immunogen | Peptide corresponding to amino acids near the C-terminus of human DR5 precursor Swiss Num.: Q9ER62 |
| Format | State: Liquid Ig fraction Purification: Affinity chromatography BufferSystem: 1x PBS containing 0.02 % Sodium Azide |
| Applications | Western Blot: 1.0 - 2.0 µg/ml.
Positive Control: HeLa whole cell lysate. |
| Specificity | Anti-DR5 reacts with DR5 at the molecular weight of approximately 60-70 kDa.
It shows no cross reactivity towards DR4. Species: Human, mouse. |
| Storage | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. |
| References | 1. Pan, G. et al. Science 277, 815 (1997).
2. Sheridan, JP. et al. Science 277, 818 (1997). 3. Walczak, H. et al. EMBO J 16, 5386 (1997). 4. MacFarlane, M. et al. J. Biol. Chem.272, 25417 (1997). 5. Screaton, GR. et al. Curr. Biol. 7, 693 (1997). 6. Wu, GS. et al. Nat. Genet 17, 141 (1997). 7. Chaudhary PM. et al. Immunity 7, 821 (1997). |
| Pictures | Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with anti-DR5 at 2 µg/ml |
12 Secondary Antibodies
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / US$ 295 | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / US$ 285 | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / US$ 285 | |||||
| R1364TR | Rabbit IgG (H&L) | ||||||
| Goat | Texas Red | 2 mg / US$ 295 | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / US$ 295 | |||||
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / US$ 325 | |||||
| R1458C2 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / US$ 445 | |||||
| R1458C3 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / US$ 445 | |||||
| R1458C35 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3.5 | 1 mg / US$ 445 | |||||
| R1458C5 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / US$ 445 | |||||
| R1458C55 | Rabbit IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5.5 | 1 mg / US$ 445 | |||||
| R1427R | Rabbit IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / US$ 455 | |||||
Click here to see all secondary antibodies for 'SP6247P CD262 / TNFRSF10B / KILLER '.
