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AF5610-1: Immunohistochemistry on human tonsil frozen sections using Collagen type I antibody AF5610-1.

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AF5610-1 Collagen type I antibody

Rated with 5 stars
see related secondary antibodies
search for all Collagen type I
0.1 mg / €200.00
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Delivery time: 3-5 workingdays
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Quick Overview

Mouse anti Human Collagen type I I-8H5

Product Description for Collagen type I

Properties for Collagen type I

ManufacturerAcris Antibodies GmbH
Quantity0.1 mg
ReactivityHuman
PresentationPurified
ApplicationsFrozen sections, Western blot / Immunoblot
IsotypeIgG2a
HostMouse
CloneI-8H5
PDF datasheetview datasheet
Shipping toWorldwide

Datasheet Extract

SynonymsCOL1A1, COL1A2, Alpha-1 type I collagen, Alpha-2 type I collagen
Swiss Prot Num P02452
Product TypeAntibodies
Recommended Isotype ControlAM03096PU-N
StorageStore the antibody at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
ReferencesMayne, R. et al. Isolation and partial characterization of basement membrane-link collagens from bovine thoracic aorta. Artery, 7. 262-280, 1980
Muragaki, Y. et al., Experimental study on alteration of collagen metabolism in liver fibrosis. J. Wakayama Med. Soc., 36. 195-208, 1985 (in Japanese)
Kumagai, J. et al. (1994) Immunohistochemical distribution of type I, II and III collagens in the rabbit supraspinatus tendon insertion. J. Anat. 185:279-284
Marijianowski, M.M.H. et al. Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ration: A quantitative assessment. J. Am. College Cardiol., 25. 1263-1272, 1995
FormatReconstitution: Reconstitute in 0.5 ml distilled water.
 State: Lyophilized
 Purification: Protein A affinity purified immunoglobulin fraction
 Buffer System: 0.1 M Na-Phosphate buffer, pH 7.0 containing 0.5% protease-free bovine serum albumin and Kathon as a preservative
Specificity The antibody specifically reacts with human Collagen type I and cross-reacts with rabbit Collagen type I.
ApplicationImmunohistochemistry on frozen sections (1-10 µg/ml).
Western blotting (4 µg/ml, non-denaturing, non-reducing conditions, use 4-6% PAGE, bands are observed at 120 kD and 300 kD).
BackgroundCollagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.

Secondary Antibodies for Collagen type I

Catalog No.Name / HostPresentationReactivity 
R1253AP Mouse IgG (H&L)
  Rabbit AP 1 mg / 190 Euro
   
R1253B Mouse IgG (H&L)
  Rabbit Biotin 2 mg / 170 Euro
   
R1253F Mouse IgG (H&L)
  Rabbit FITC 2 mg / 160 Euro
   
R1253HRP Mouse IgG (H&L)
  Rabbit HRP 2 mg / 180 Euro
   
R1253TR Mouse IgG (H&L)
  Rabbit Texas Red 2 mg / 170 Euro
   
R1403R Mouse IgG (H&L) F(ab')2 Fragment
  Rabbit PE 1 ml / 290 Euro
   
R1405R Mouse IgG (H&L) F(ab')2 Fragment
  Goat PE 1 ml / 290 Euro
   
R1455R Mouse IgG (H&L) F(ab')2 Fragment multi-species ads.
  Donkey PE 1 ml / 290 Euro
   
R1457C2 Mouse IgG (H&L) multi-species ads.
  Goat Cy2 1 mg / 270 Euro
   
R1457C3 Mouse IgG (H&L) multi-species ads.
  Goat Cy3 1 mg / 250 Euro
   
R1457C5 Mouse IgG (H&L) multi-species ads.
  Goat Cy5 1 mg / 250 Euro
   
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