14-3-3 protein eta - AP05566SU-N | acris-antibodies.com

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Product Description for 14-3-3 protein eta

Rabbit anti Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep 14-3-3 protein eta.
Presentation: Serum
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for 14-3-3 protein eta

Product Category	Antibodies
Quantity	0.1 ml
Synonyms	FocusOn116, Protein AS1, YWHA1, YWHAH
Presentation	Serum
Reactivity	Bov, Chk, Hu, Ms, Rb, Rt, Sh
Applications	P, WB
Clonality	Polyclonal
Host	Rabbit
Isotype	IgG
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: Q04917 Immunogen: Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 eta. AA Sequence: `Ac.GDREQLLQRARC` Genename: 7533 Remarks: Antiserum Preparation: Antisera to sheep 14-3-3 eta were raised by repeated immunisations of rabbit with highly purified antigen.
Antibody type	Ab
Application	Western Blot: Detects a band of approximately 30kDa in HEK293 cell lysates. Immunohistochemistry on Paraffin Sections: 1/3200. Requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Background	14-3-3 eta is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 eta is expressed principally in the brain although it is expressed at low levels in other tissues. The protein binds alphasynuclein, forming part of lewy bodies in parkinsons disease and has been linked to earlyonset schizophrenia. The eta isoform binds both gremlin 1, which is overexpressed in human cancers, and the DAL1/Protein 4.1B tumour suppressor. Furthermore the glucocortcoid receptor is positively regulated by 14-3-3eta. AHP1046 may not react with recombinant proteins that are not Nacetylated.
General Readings	Martin, H. et al. (1993) Antibodies against major brain isoforms of 1433 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303. Aitken, A. et al. (2006) 1433 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162-172.
Storage	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	State: Liquid Serum containing 0.09% Sodium Azide as preservative Serum
Species Reactivity	Species reactivity (expected): Mammals. Species reactivity (tested): Sheep, Mouse, Human, Bovine, Chicken, Rabbit, Rat.
Specificity	Specificity: This antibody recognises 14-3-3 eta in all mammals. This antibody may not react with recombinant proteins that are not N-acetylated.
Gene ID	7533
FocusOn and Reviews	FocusOns: Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) - FocusOn 116
Targets	14-3-3 protein eta antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for 14-3-3 protein eta (4 products)

Catalog No.	Species	Pres.	Purity		Source
AR09102PU-L	14-3-3 protein eta (1-246, His-tag)
	Human	Purified	≥ 95		E. coli		0.5 mg / €750.00
							Acris Antibodies GmbH
AR09102PU-N	14-3-3 protein eta (1-246, His-tag)
	Human	Purified	≥ 95		E. coli		0.1 mg / €300.00
							Acris Antibodies GmbH
H00007533-Q01-10	14-3-3 protein eta
	Human				in vitro transl.		10 µg / €350.00
							Abnova Taiwan Corp.
H00007533-Q01-25	14-3-3 protein eta
	Human				in vitro transl.		25 µg / €500.00
							Abnova Taiwan Corp.

Positive controls for 14-3-3 protein eta (1 products)

Catalog No.	Species	Pres.	Purity		Source
NBL1-17950	14-3-3 eta Lysate
							0.1 mg / €370.00
							Novus Biologicals Inc.

Recommended Secondary Antibodies for 14-3-3 protein eta (6 products)

Catalog No.	Host	Clone/Iso.	Pres.		React.	Applications
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat		AP
							Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat		Biotin
							Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat		FITC
							Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat		HRP
							Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat		TRITC
							Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey		PE
							Acris Antibodies GmbH

Click here to see all secondary antibodies for 14-3-3 protein eta

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