Alpha-Synuclein / SNCA (C-term) - AP13472PU-N

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Product Description for Alpha-Synuclein / SNCA

Rabbit anti Human Alpha-Synuclein / SNCA.
Properties: (C-term)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for Alpha-Synuclein / SNCA

Product Category	Antibodies
Quantity	0.1 mg
Synonyms	FocusOn131, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Presentation	Purified
Reactivity	Hu
Applications	E, P, WB
Clonality	Polyclonal
Host	Rabbit
Isotype	Ig
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: P37840 Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the C-terminal region of human Alpha-synuclein that recognizes both NACP112 and NCAP140. Genename: 6622
Property	C-term
Antibody type	Ab
Control peptide	AP13472CP-N
Application	ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Background	Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP112) lacks an alternate in-frame segment, compared to variant NACP140, resulting in a shorter protein (isoform NACP112) that has a distinct C-terminus, compared to isoform NACP140. This antibody recognizes both NACP112 and NCAP140.
Caution	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration	0.25 mg/ml
General Readings	Kumru, H., et al., Ann. Neurol. 56(4):599-603 (2004). Pigullo, S., et al., Parkinsonism Relat. Disord. 10(6):357-362 (2004). Yao, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(29):10810-10814 (2004). West, A.B., et al., J. Biol. Chem. 279(28):28896-28902 (2004). Wang, F., et al., Genes Chromosomes Cancer 40(2):85-96 (2004).
Storage	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS Buffer System: PBS with 0.09% (W/V) sodium azide State: Liquid purified Ig Purified
Specificity	Specificity: This antibody reacts to Alpha-Synuclein. Species: Human.
Gene ID	6622
FocusOn and Reviews	FocusOns: Antibodies for Parkinson’s Disease - FocusOn 131
Targets	Alpha-Synuclein / SNCA antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for Alpha-Synuclein / SNCA (42 products)

Catalog No.	Species	Pres.	Purity	Source
SA6000	Alpha-Synuclein / SNCA (A30P Mutant)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6000X	Alpha-Synuclein / SNCA (A30P Mutant)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6001	Alpha-Synuclein / SNCA
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6001FD	Alpha-Synuclein / SNCA (1-140)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6001X	Alpha-Synuclein / SNCA (1-140)
	Human	Purified	> 95 %	E. coli	1 mg / €520.00
					Acris Antibodies GmbH
SA6001XFD	Alpha-Synuclein / SNCA (1-140)
	Human	Purified	> 95 %	E. coli	1 mg / €520.00
					Acris Antibodies GmbH
SA6002	Alpha-Synuclein / SNCA (A53T Mutant)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6002X	Alpha-Synuclein / SNCA (A53T Mutant)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6003	Alpha-Synuclein / SNCA (A30P/A53T Mutant)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6003X	Alpha-Synuclein / SNCA (A30P/A53T Mutant)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6004	Alpha-Synuclein / SNCA (Delta-Nac Mutant)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6004X	Alpha-Synuclein / SNCA (Delta-Nac Mutant)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6005	Alpha-Synuclein / SNCA (NACP112)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6005X	Alpha-Synuclein / SNCA (NACP112)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6006	Alpha-Synuclein / SNCA (61-140)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6006X	Alpha-Synuclein / SNCA (61-140)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6007	Alpha-Synuclein / SNCA (96-140)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6007X	Alpha-Synuclein / SNCA (96-140)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6008	Alpha-Synuclein / SNCA (1-60)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6008X	Alpha-Synuclein / SNCA (1-60)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6009	Alpha-Synuclein / SNCA (E46K Mutant)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6009X	Alpha-Synuclein / SNCA (E46K Mutant)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
SA6010	Alpha-Synuclein / SNCA (1-95)
	Human	Purified	> 95 %	E. coli	0.1 mg / €230.00
					Acris Antibodies GmbH
SA6010X	Alpha-Synuclein / SNCA (1-95)
	Human	Purified	> 95 %	E. coli	0.5 mg / €540.00
					Acris Antibodies GmbH
NBC1-07002	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18320	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18321	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18322	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18323	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18324	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18325	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18326	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18327	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18328	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18331	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
NBC1-18332	Alpha-Synuclein / SNCA
					0.1 mg / €280.00
					Novus Biologicals Inc.
H00006622-P01-10	Alpha-Synuclein / SNCA
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00006622-P01-25	Alpha-Synuclein / SNCA
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.
H00006622-Q01-10	Alpha-Synuclein / SNCA
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00006622-Q01-25	Alpha-Synuclein / SNCA
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.
PR27158-20	Alpha-Synuclein / SNCA
	Human	Purified	> 95 %	E. coli	20 µg / €190.00
					Neuromics Antibodies
LF-P0310	Alpha-Synuclein / SNCA
	Human		> 95 %	E. coli	0.2 mg / €270.00
					Young In Frontier Co. Ltd.

Positive controls for Alpha-Synuclein / SNCA (1 products)

Catalog No.	Species
NBL1-16274	alpha Synuclein Lysate
		0.1 mg / €370.00
		Novus Biologicals Inc.

Recommended Secondary Antibodies for Alpha-Synuclein / SNCA (6 products)

Catalog No.	Host	Pres.
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat	AP
			Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat	Biotin
			Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat	FITC
			Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat	HRP
			Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat	TRITC
			Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey	PE
			Acris Antibodies GmbH