Amyloid beta A4 protein / APP - AP15347PU-S

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Product Description for Amyloid beta A4 protein / APP

Rabbit anti Human, Mouse, Rat Amyloid beta A4 protein / APP.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Amyloid beta A4 protein / APP

Product Category	Antibodies
Quantity	0.1 ml
Synonyms	ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, FocusOn068, FocusOn130, PreA4, Protease nexin-II
Presentation	Purified
Reactivity	Hu, Ms, Rt
Applications	P, WB
Clonality	Polyclonal
Host	Rabbit
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: P05067 Immunogen: A synthetic peptide corresponding to N-terminal of human APP Genename: 351
Antibody type	Ab
Application	Western blot: 1.0µg/ml for 2hours. Immunohistochemistry on paraffin sections: 1/100 for 10 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Positive Control: Brain
Background	Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver; ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri; moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Storage	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Format	Buffer System: 10mM PBS, pH 7.4 containing 1% BSA as stabilizer and 0,09% Sodium Azide as preservative State: Liquid purified Ig fraction Purified
Species Reactivity	Species reactivity (expected): Mouse and Rat. Species reactivity (tested): Human.
Specificity	Specificity: This antibody recognizes APP (b-APP770), MW 110kDa. Predicted to recognize beta-APP695 and beta-APP751. Amyloid precursor protein (APP) and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.
Gene ID	351
FocusOn and Reviews	FocusOns: Antibodies for Alzheimer’s Disease - FocusOn 130
Targets	Amyloid beta A4 protein / APP antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for Amyloid beta A4 protein / APP (27 products)

Catalog No.	Species	Pres.	Purity	Source
NBP1-44962	Amyloid beta (1-11)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44963	Amyloid beta (1-15)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44964-.05	Amyloid beta (1-40)
	Human	Purified			50 µg / €230.00
					Novus Biologicals Inc.
NBP1-44964-10	Amyloid beta (1-40)
	Human	Purified			10 mg / €830.00
					Novus Biologicals Inc.
NBP1-44967-1	Amyloid beta (1-42)
	Human	Purified			1 mg / €290.00
					Novus Biologicals Inc.
NBP1-44967-10.0	Amyloid beta (1-42)
	Human	Purified			10 mg / €1,210.00
					Novus Biologicals Inc.
NBP1-44969-1.0	Amyloid beta (3-42 pyrGlu3)
	Human	Purified			1 mg / €330.00
					Novus Biologicals Inc.
NBP1-44969-50	Amyloid beta (3-42 pyrGlu3)
	Human	Purified			50 µg / €230.00
					Novus Biologicals Inc.
NBP1-44970	Amyloid beta (3-42)
	Human	Purified			1 mg / €330.00
					Novus Biologicals Inc.
NBP1-44974	Amyloid beta (11-20)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44975-1.0	Amyloid beta (11-42 pyrGlu11)
	Human	Purified			1 mg / €290.00
					Novus Biologicals Inc.
NBP1-44975-50	Amyloid beta (11-42 pyrGlu11)
	Human	Purified			50 µg / €230.00
					Novus Biologicals Inc.
NBP1-44977	Amyloid beta (12-28)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44978	Amyloid beta (17-28)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44979	Amyloid beta (29-40)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44980	Amyloid beta (29-42)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44971	Amyloid beta A4 protein / APP
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44976	Amyloid beta A4 protein / APP
	Human	Purified			1 mg / €250.00
					Novus Biologicals Inc.
GTX27874	Amyloid beta A4 protein / APP control peptide
					50 µg / €230.00
					GeneTex Inc.
GTX27875	Amyloid beta A4 protein / APP control peptide
					50 µg / €230.00
					GeneTex Inc.
H00000351-P01-10	Amyloid beta A4 protein / APP
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00000351-P01-25	Amyloid beta A4 protein / APP
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.
H00000351-P02-10	Amyloid beta A4 protein / APP
	Human	Purified			10 µg / €350.00
					Abnova Taiwan Corp.
H00000351-P02-25	Amyloid beta A4 protein / APP
	Human	Purified			25 µg / €500.00
					Abnova Taiwan Corp.
PR15037CF-10	Amyloid beta A4 protein / APP
	Human	Purified	> 90 %	NSO cells	10 µg / €390.00
					Neuromics Antibodies
LF-P0050	Amyloid beta A4 protein / APP
	Human		> 95 %	E. coli	0.5 mg / €260.00
					Young In Frontier Co. Ltd.
LF-P0051	Amyloid beta A4 protein / APP
	Human		> 95 %	E. coli	0.5 mg / €260.00
					Young In Frontier Co. Ltd.

Positive controls for Amyloid beta A4 protein / APP (2 products)

Catalog No.	Species
NBL1-07632	Amyloid beta precursor protein Lysate
		0.1 mg / €500.00
		Novus Biologicals Inc.
H00010342-T01	TFG 293T Cell Transient Overexpression Lysate (Denatured)
		0.1 ml / €240.00
		Abnova Taiwan Corp.

Recommended Secondary Antibodies for Amyloid beta A4 protein / APP (6 products)

Catalog No.	Host	Pres.
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat	AP
			Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat	Biotin
			Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat	FITC
			Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat	HRP
			Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat	TRITC
			Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey	PE
			Acris Antibodies GmbH