Amyloid beta + APP - AP07841PU-N | acris-antibodies.com

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Product Description for Amyloid beta + APP

Rabbit anti Human Amyloid beta + APP.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for Amyloid beta + APP

Product Category	Antibodies
Quantity	50 µg
Synonyms	ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, FocusOn068, FocusOn130, PreA4, Protease nexin-II
Presentation	Aff - Purified
Reactivity	Hu
Applications	E, ICC/IF, IP, P, WB
Clonality	Polyclonal
Host	Rabbit
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: P05067 Immunogen: Beta Amyloid peptide conjugated to KLH using maleimide AA Sequence: `D-A-E-F-R-H-D-S-G-Y-E-V-H-H` Genename: 351 Remarks: The sequence corresponds to aa 1-14 of Human beta Amyloid.
Antibody type	Ab
Application	ELISA. Western blot. Immunoprecipitation. Immunofluorescence. Immunohistochemistry on Paraffin Sections (5 µg/ml). This APP antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody Rabbit IgG, followed by alkaline phosphatase-streptavidin and chromogen.
Background	Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.
Concentration	0.62 mg/ml
Storage	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid cycles of freezing and thawing. Shelf life: One year from despatch.
Format	Purification: Immunoaffinity Chromatography Buffer System: 0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preservative State: Liquid purified IgG fraction Aff - Purified
Specificity	Specificity: This antibody detects Amyloid Beta (A4) Precursor Protein (APP). Species: Human.
Gene ID	351
FocusOn and Reviews	FocusOns: Antibody Panel to beta Amyloid - FocusOn 068 Antibodies for Alzheimer’s Disease - FocusOn 130
Targets	Amyloid beta A4 protein / APP antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for Amyloid beta + APP (27 products)

Catalog No.	Species	Pres.	Purity	Source
NBP1-44962	Amyloid beta (1-11)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44963	Amyloid beta (1-15)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44964-.05	Amyloid beta (1-40)
	Human	Purified			50 µg / €230.00
					Novus Biologicals Inc.
NBP1-44964-10	Amyloid beta (1-40)
	Human	Purified			10 mg / €830.00
					Novus Biologicals Inc.
NBP1-44967-1	Amyloid beta (1-42)
	Human	Purified			1 mg / €290.00
					Novus Biologicals Inc.
NBP1-44967-10.0	Amyloid beta (1-42)
	Human	Purified			10 mg / €1,210.00
					Novus Biologicals Inc.
NBP1-44969-1.0	Amyloid beta (3-42 pyrGlu3)
	Human	Purified			1 mg / €330.00
					Novus Biologicals Inc.
NBP1-44969-50	Amyloid beta (3-42 pyrGlu3)
	Human	Purified			50 µg / €230.00
					Novus Biologicals Inc.
NBP1-44970	Amyloid beta (3-42)
	Human	Purified			1 mg / €330.00
					Novus Biologicals Inc.
NBP1-44974	Amyloid beta (11-20)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44975-1.0	Amyloid beta (11-42 pyrGlu11)
	Human	Purified			1 mg / €290.00
					Novus Biologicals Inc.
NBP1-44975-50	Amyloid beta (11-42 pyrGlu11)
	Human	Purified			50 µg / €230.00
					Novus Biologicals Inc.
NBP1-44977	Amyloid beta (12-28)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44978	Amyloid beta (17-28)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44979	Amyloid beta (29-40)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44980	Amyloid beta (29-42)
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44971	Amyloid beta A4 protein / APP
	Human	Purified			1 mg / €230.00
					Novus Biologicals Inc.
NBP1-44976	Amyloid beta A4 protein / APP
	Human	Purified			1 mg / €250.00
					Novus Biologicals Inc.
GTX27874	Amyloid beta A4 protein / APP control peptide
					50 µg / €230.00
					GeneTex Inc.
GTX27875	Amyloid beta A4 protein / APP control peptide
					50 µg / €230.00
					GeneTex Inc.
H00000351-P01-10	Amyloid beta A4 protein / APP
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00000351-P01-25	Amyloid beta A4 protein / APP
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.
H00000351-P02-10	Amyloid beta A4 protein / APP
	Human	Purified			10 µg / €350.00
					Abnova Taiwan Corp.
H00000351-P02-25	Amyloid beta A4 protein / APP
	Human	Purified			25 µg / €500.00
					Abnova Taiwan Corp.
PR15037CF-10	Amyloid beta A4 protein / APP
	Human	Purified	> 90 %	NSO cells	10 µg / €390.00
					Neuromics Antibodies
LF-P0050	Amyloid beta A4 protein / APP
	Human		> 95 %	E. coli	0.5 mg / €260.00
					Young In Frontier Co. Ltd.
LF-P0051	Amyloid beta A4 protein / APP
	Human		> 95 %	E. coli	0.5 mg / €260.00
					Young In Frontier Co. Ltd.

Positive controls for Amyloid beta + APP (2 products)

Catalog No.	Species
NBL1-07632	Amyloid beta precursor protein Lysate
		0.1 mg / €500.00
		Novus Biologicals Inc.
H00010342-T01	TFG 293T Cell Transient Overexpression Lysate (Denatured)
		0.1 ml / €240.00
		Abnova Taiwan Corp.

Recommended Secondary Antibodies for Amyloid beta + APP (6 products)

Catalog No.	Host	Pres.
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat	AP
			Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat	Biotin
			Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat	FITC
			Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat	HRP
			Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat	TRITC
			Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey	PE
			Acris Antibodies GmbH