AP05554PU-N Apolipoprotein J (Apo J) antibody

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0.1 mg / €300.00
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Rabbit anti Human Apolipoprotein J (Apo J)

AP05554PU-N

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  • AP05554PU-N

Product Description for Apolipoprotein J (Apo J)

Rabbit anti Human Apolipoprotein J (Apo J).
Presentation: Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for Apolipoprotein J (Apo J)

Product Category Antibodies
Quantity 0.1 mg
Synonyms 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, FocusOn036, FocusOn130, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH

Datasheet Extract

Immunogen
Swiss Prot Num:
P10909
Immunogen:
Recombinant human clusterin isoform 1.
Genename:
1191
Antibody type Ab
Application Western Blot: 0.5 - 1.0 µg/ml; detects a band of approximately 60kDa in human brain tissue lysate.
Background Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms; a proapoptotic nuclear form, of 49kDa, and a prosurvival secretory form with a molecular weight of 75-80kDa. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis.
Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumours. Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. It has been shown to be upregulated in Alzheimer
Caution (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Concentration 1.0mg/ml
General Readings
  • Trougakos, I. and Gonos, E. (2002) Clusterin/Apolipoprotein J in human aging and cancer. Int. J. Biochem. Cell Biol. 34: 1430 - 1448.
  • Calero, M. et al. (2005) Clusterin and Alzheimers disease. Subcell. Biochem. 38: 273 - 298.
  • Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA. Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem. 2003 Mar 28;278(13):11590-600. Epub 2003 Jan 24. PubMed PMID: 12551933.
  • Carreras I, Garrett-Young R, Ullman MD, Eisenhauer PB, Fine RE, Wells JM, et al. Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells. J Neurosci Res. 2005 Feb 15;79(4):495-502. PubMed PMID: 15635600.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
Phosphate buffered saline containing 0.02% Sodium Azide (NaN3)
State:
Liquid purified IgG
Purified
Specificity
Specificity:
This antibody recognises clusterin (also known as apolipoprotein J).
Gene ID 1191
FocusOn and Reviews
FocusOns:
Targets

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