ATP2A2 / SERCA2 - SM5113 | acris-antibodies.com

Product Description for ATP2A2 / SERCA2

Mouse anti Canine, Guinea Pig, Human, Mouse, Rabbit, Rat ATP2A2 / SERCA2 2A7-A1.
Presentation: Ascites
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for ATP2A2 / SERCA2

Product Category	Antibodies
Quantity	0.1 ml
Synonyms	ATP2B, Calcium pump 2 ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Review 012, SR Ca(2+)-ATPase 2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, slow twitch skeletal muscle isoform
Presentation	Ascites
Reactivity	Can, GP, Hu, Ms, Rb, Rt
Applications	IP, WB
Clonality	Monoclonal
Clone	2A7-A1
Host	Mouse
Isotype	IgG2a
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH
Material safety datasheet	MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen	Swiss Prot Num: P16615 Immunogen: Purified canine cardiac sarcoplasmic reticulum vesicles. Genename: 488
Antibody type	Ab
Application	Immunocytochemistry: 1/250. Western Blot: 1/1,000; detects an ~110 kDa protein representing SERCA2 ATPase in rat cardiac tissue. Immunoprecipitation.
Background	ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are comprised of a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
General Readings	Circulation, 90(2): 653-657, 1994. Proc. Natl. Acad. Sci., 91: 2694-2698, 1994. J. Biol. Chem, 271(10): 5536-5544, 1996. FASEB 19(1):53-61, 2005. PNAS vol. 101 no. 25, 9199-9204, Jun 2004 J Appl Physiol, Dec 1999; 87: 2143 Am J Physiol Heart Circ Physiology 2005, manuscript number doi:10.1152/ajpheart.00424.2004 Circulation Research Feb 2005 doi:10.1161/01.RES.0000160609.98948.25 Physiol Genomics 22: 118-126 Mar 2005 Diabetes 54:1573-1580, 2005. Am J Physiol Heart Circ Physiol Vol. 286, H68-75 Jan 2004 Am J Physiol Heart Circ Physiol 286: H1322–H1330, Apr 2004 JBC Vol. 279, No. 20, Issue of May 14, pp. 21383–21393, 2004 Circ. Research Vol. 96, 1006-1013, 2005 J Appl Physiol Vol 97, 484-490, 2004 AJP-Endo, Vol 284, 597-610, 2003 J. Am. Coll. Cardiol. Vol 42, 1666-1673, Nov 2003 Diabetes, Vol 51: 1166, Apr 2002 Am. J. Physiol. Heart Circ. Physiol. 283(4):H1616-H1626, 2002. JBC 277(47):44740-44746, 2002. Am. J. Physiol. Heart Circ. Physiol. 283(2):H576-H583, 2002. Am. J. Heart Circ. Physiol. 283(6):H2450-H2457, 2002. J Appl Physiol, Jul 2000; 89: 38. Am J Physiol Regulatory Integrative Comp Physiol, Jul 2000; 279: 152. Am J Physiol Regulatory Integrative Comp Physiol, Mar 2000; 278: 598. Circ. Res., Mar 1999; 84: 562 - 570. J. Clin. Invest., Jul 1998; 102: 72. J. Biol. Chem., Oct 2006; 281: 31894 - 31908 Circ. Res., Mar 2001; 88: 415 - 421. Am J Physiol Heart Circ Physiol, Oct 1999; 277: H1418 - H1428. JBC 277(30):26725-26728, 2002. Circulation 106(4):407-411, 2002. Circ. Res. 91(11):1015-1022, 2002. JPET Fast Forward, doi:10.1124/jpet.105.099432, Jan 2006 Circ. Res., Vol 93: 230-237, Aug 2003 Circulation, Vol 108: 929-932, Aug 2003 Circulation, Jun 2006; 113: 2724 - 2732. Am J Physiol Cell Physiol Vol 287, C1300-C1310, Nov 2004 Am J Physiol Heart Circ Physiol Bol 285, H2605-H2613, Dec 2003 PNAS Vol 101, No 8, 2241-2246, Feb 2004 JBC Vol 280, No 48, 40337-40346, Dec 2005 AJP-Heart Vol 285, 2657-2662, Dec 2003 J Appl Physiol, Vol 92: 18, Jan 2002 PNAS Vol 101, No 45, 15944-15948, Nov 2004 PNAS Vol 101, No 47, 16683-16688, Nov 2004 FASEB Journal Vol. 16 1310-1312, 2002. Am. J. Physiol. 277: H584-H594, 1999. Am J Physiol Heart Circ Physiology 10.1152/ajpheart.00957.2003 2005 Am J Physiol Heart Circ Physiology 2005, manuscript number doi:10.1152/ajpheart.00873.2004. J. Biochem., 340:657-669, 1999 FEBS Letters., 443:308-312, 1999. Circ Res Vol 94 794-801, Apr 2004 AJP-Heart 286, 2219-2228, Jun 2004 Am. J. Physiol. Heart Circ. Physiol. 277(4):H1418-1428, 1999. J. Appl. Physiol. 97:484-490, 2004. Circulation, Feb 2000; 101: 790 - 796.
Storage	Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	State: Liquid Ascites containing 0.05% Sodium Azide as preservative. Ascites
Specificity	Specificity: This antibody detects sarcoplasmic or endoplasmic reticulum calcium (SERCA) 2 ATPase. Species: Canine, Rat, Human, Rabbit, Mouse, Guinea Pig.
Gene ID	488
FocusOn and Reviews	Reviews: Antibodies to ATPase Enzymes - Product Review 12
Targets	ATP2A2 / SERCA2 antibody

Accessory Products

Recommended Secondary Antibodies for ATP2A2 / SERCA2 (8 products)

Catalog No.	Host	Pres.
R1253AP	Mouse IgG (H+L chain) antibody
	Rabbit	AP
			Acris Antibodies GmbH
R1253B	Mouse IgG (H+L chain) antibody
	Rabbit	Biotin
			Acris Antibodies GmbH
R1253F	Mouse IgG (H+L chain) antibody
	Rabbit	FITC
			Acris Antibodies GmbH
R1253HRP	Mouse IgG (H+L chain) antibody
	Rabbit	HRP
			Acris Antibodies GmbH
R1253TR	Mouse IgG (H+L chain) antibody
	Rabbit	Texas Red
			Acris Antibodies GmbH
R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Rabbit	PE
			Acris Antibodies GmbH
R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Goat	PE
			Acris Antibodies GmbH
R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
			Acris Antibodies GmbH