SP5341P ATP2B1 / PMCA1 antibody

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0.1 mg / €380.00
Please visit the appropriate website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Rat ATP2B1 / PMCA1

SP5341P

Product Description for ATP2B1 / PMCA1

Rabbit anti Human, Rat ATP2B1 / PMCA1.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for ATP2B1 / PMCA1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1, Plasma membrane calcium-transporting ATPase 1
Presentation Aff - Purified
Reactivity Hu, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P20020
Immunogen:
Synthetic peptide corresponding to the residues of rat PMCA1 ATPase.
AA Sequence:
A(5) N N S V A Y S G V K N S I K E A N(22)
Genename:
490
Application ELISA.
Western Blot: 1:1,000; detects ~134 kDa and ~130 kDa proteins representing PMCA1a and 1b ATPase from rat, human and porcine samples.
Immunohistochemistry on paraffin and frozen sections.
Background The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/potassium pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
Concentration 1.0 mg/ml
General Readings
  1. IOVS, 44(10): 4395-4400, 2003
  2. JBC Oct 2005 Manuscript M506950200
  3. JBC Papers in Press, Manuscript M506950200, Oct 2005
  4. Invest. Ophthalmol. Vis. Sci., Vol 44: 4395-4399, Oct 2003
  5. Molecular Vision, 11:169-178, 2005
  6. Biochem. J., 316:353-359, 1996.
  7. J. Biol. Chem., 272:23741-23747, 1997.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS with 1 mg/ml BSA and 0.05% sodium azide
State:
Liquid purified IgG
Aff - Purified
Specificity
Specificity:
This antibody detects calcium pump of the plasma membrane 1a (PMCA1a ATPase) and 1b.
Species:
Porcine, Rat, Human.
FocusOn and Reviews
Reviews:

Accessory Products

Proteins and/or Positive Controls

Proteins for ATP2B1 / PMCA1 (2 products)

Catalog No. Species Pres. Purity   Source  
H00000490-Q01-10

ATP2B1 / PMCA1

ATP2B1 / PMCA1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €350.00
  Abnova Taiwan Corp.
H00000490-Q01-25

ATP2B1 / PMCA1

ATP2B1 / PMCA1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.
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