BAG1 (N-term) - AP05586PU-S | acris-antibodies.com

Product Description for BAG1

Rabbit anti Human, Mouse BAG1.
Properties: (N-term)
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for BAG1

Product Category	Antibodies
Quantity	50 µg
Synonyms	BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP, RAP46, Review 004
Presentation	Purified
Reactivity	Hu, Ms
Applications	WB
Clonality	Polyclonal
Host	Rabbit
Isotype	IgG
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: Q99933 Immunogen: 14 amino acid peptide near the amino terminus of human BAG1. Genename: 573
Property	N-term
Antibody type	Ab
Application	Western blot: 1 - 2 µg/ml; detects a band of approximately 35kDa in PC3 cell lysate.
Background	BAG1 is a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms; a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L). BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.
Concentration	1.0 mg/ml
General Readings	Götz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, et al. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci. 2005 Sep;8(9):1169-78. Epub 2005 Aug 21. PubMed PMID: 16116448. Liman J, Ganesan S, Dohm CP, Krajewski S, Reed JC, Bähr M, et al. Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol Cell Biol. 2005 May;25(9):3715-25. PubMed PMID: 15831476. Krajewska, M. et al. (2006) Expression of BAG1 protein correlates with aggressive behavior of prostate cancers. Prostate. 66: 801 - 810. Clemo NK, Arhel NJ, Barnes JD, Baker J, Moorghen M, Packham GK, et al. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem Soc Trans. 2005 Aug;33(Pt 4):676-8. PubMed PMID: 16042572.
Storage	Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format	Purification: Affinity chromatography Buffer System: Phosphate buffered saline containing 0.02% Sodium Azide State: Liquid Ig fraction Purified
Species Reactivity	Species reactivity (tested): Human, Mouse.
Specificity	Specificity: This antibody detects an epitope within the N-terminal (NT) region of Bcl-2 associated athanogene-1 (BAG1).
Gene ID	573
FocusOn and Reviews	Reviews: Antibodies to bcl-2 Protein Family - Product Review 04
Targets	BAG1 antibody

Accessory Products

Proteins and/or Positive Controls

Proteins for BAG1 (7 products)

Catalog No.	Species	Pres.	Purity	Source
AR09407PU-L	BAG1 (1-230)
	Human	Purified	> 90 %	E. coli	0.5 mg / €670.00
					Acris Antibodies GmbH
AR09407PU-N	BAG1 (1-230)
	Human	Purified	> 90 %	E. coli	0.1 mg / €250.00
					Acris Antibodies GmbH
NBP1-41131	BAG1
					0.1 mg / €310.00
					Novus Biologicals Inc.
H00000573-P01-10	BAG1
	Human	Purified			10 µg / €350.00
					Abnova Taiwan Corp.
H00000573-P01-25	BAG1
	Human	Purified			25 µg / €500.00
					Abnova Taiwan Corp.
H00000573-Q01-10	BAG1
	Human			in vitro transl.	10 µg / €350.00
					Abnova Taiwan Corp.
H00000573-Q01-25	BAG1
	Human			in vitro transl.	25 µg / €500.00
					Abnova Taiwan Corp.

Positive controls for BAG1 (1 products)

Catalog No.	Species
H00000573-T01	BAG1 Lysate(Denatured)
		0.1 ml / €240.00
		Abnova Taiwan Corp.

Recommended Secondary Antibodies for BAG1 (6 products)

Catalog No.	Host	Pres.
R1364AP	Rabbit IgG (H+L chain) antibody
	Goat	AP
			Acris Antibodies GmbH
R1364B	Rabbit IgG (H+L chain) antibody
	Goat	Biotin
			Acris Antibodies GmbH
R1364F	Rabbit IgG (H+L chain) antibody
	Goat	FITC
			Acris Antibodies GmbH
R1364HRP	Rabbit IgG (H+L chain) antibody
	Goat	HRP
			Acris Antibodies GmbH
R1364T	Rabbit IgG (H+L chain) antibody
	Goat	TRITC
			Acris Antibodies GmbH
R1427R	Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
	Donkey	PE
			Acris Antibodies GmbH

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AP05586PU-S BAG1 (N-term) antibody

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Product Description for BAG1

Properties for BAG1

Datasheet Extract